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Literature summary extracted from

  • Chakraborty, B.; Paine, T.
    Aromatic ring cleavage of 2-amino-4-tert-butylphenol by a nonheme iron(II) complex: functional model of 2-aminophenol dioxygenases (2013), Angew. Chem. Int. Ed. Engl., 52, 920-924.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.6 Fe2+ required, the active site of HAD contains an iron(II) center that is coordinated by the 2-His-1-Glu facial triad Pseudomonas oleovorans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.6 3-hydroxyanthranilate + O2 Pseudomonas oleovorans
-
 2-amino-3-carboxymuconate semialdehyde
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.6 Pseudomonas oleovorans
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.13.11.6 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde reaction mechanism, overview Pseudomonas oleovorans
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.6 3-hydroxyanthranilate + O2
-
 Pseudomonas oleovorans 2-amino-3-carboxymuconate semialdehyde
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.6 HAD
-
 Pseudomonas oleovorans

General Information

EC Number General Information Comment Organism
1.13.11.6 evolution HAD belongs to the class of nonheme iron(II) enzymes and shares functional similarity with extradiol-cleaving catechol dioxygenases Pseudomonas oleovorans
1.13.11.6 additional information oxidative CC bond cleavage of 2-amino-4-tert-butylphenolate on complex nonheme iron(II) complex, [(6-Me3-TPA)FeII(4-tBu-HAP)](ClO4) is mimicking the enzyme function. The iron(II)-aminophenolate complex reacts with molecular oxygen in acetonitrile under ambient conditions, overview Pseudomonas oleovorans
1.13.11.6 physiological function the enzyme catalyzes the degradation of 3-hydroxyanthranilate to quinolinate in the presence of dioxygen Pseudomonas oleovorans