EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.4.3.3 | 3-hydroxyquinoline-2-(1H)-one | very potent inhibitor | Homo sapiens | |
1.4.3.3 | 4H-furo[3,2-b]pyrrole-5-carboxylic acid | - |
Homo sapiens | |
1.4.3.3 | 4H-thieno[3,2-b]pyrrole-5-carboxylic acid | - |
Homo sapiens | |
1.4.3.3 | 5-methylpyrazole-3-carboxylic acid | - |
Homo sapiens | |
1.4.3.3 | 6-chlorobenzo[d]isoxazol-3-ol | - |
Homo sapiens | |
1.4.3.3 | anthranilate | - |
Homo sapiens | |
1.4.3.3 | benzoate | competitive inhibitor | Homo sapiens | |
1.4.3.3 | chlorpromazine | - |
Homo sapiens | |
1.4.3.3 | D-serine | - |
Homo sapiens | |
1.4.3.3 | trifluoro-D-alanine | pseudo-substrate | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.3.3 | 1.3 | - |
D-alanine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 1.5 | - |
D-tryptophan | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 1.5 | - |
D-Dopa | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 1.5 | - |
D-tyrosine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 2.7 | - |
D-phenylalanine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 7.5 | - |
D-serine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 8.5 | - |
D-proline | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 180 | - |
glycine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 2000 | - |
D-Aspartate | at pH 7.0 and 25°C | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.4.3.3 | peroxisome | - |
Homo sapiens | 5777 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.4.3.3 | D-amino acid + H2O + O2 | Homo sapiens | - |
2-oxocarboxylate + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-kynurenine + H2O + O2 | Homo sapiens | - |
kynurenic acid + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-serine + H2O + O2 | Homo sapiens | low catalytic efficiency and substrate affinity on the physiological substrate D-serine | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.4.3.3 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.4.3.3 | brain | - |
Homo sapiens | - |
1.4.3.3 | brain cortex | - |
Homo sapiens | - |
1.4.3.3 | cerebellum | - |
Homo sapiens | - |
1.4.3.3 | glial cell | - |
Homo sapiens | - |
1.4.3.3 | medulla oblongata | - |
Homo sapiens | - |
1.4.3.3 | additional information | not detected in the forebrain | Homo sapiens | - |
1.4.3.3 | pons | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.4.3.3 | D-alanine + H2O + O2 | - |
Homo sapiens | pyruvate + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-amino acid + H2O + O2 | - |
Homo sapiens | 2-oxocarboxylate + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-aspartate + H2O + O2 | - |
Homo sapiens | oxaloacetate + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-DOPA + H2O + O2 | - |
Homo sapiens | 3,4-dihydroxyphenylpyruvic acid + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-kynurenine + H2O + O2 | - |
Homo sapiens | kynurenic acid + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-phenylalanine + H2O + O2 | - |
Homo sapiens | phenylpyruvate + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-proline + H2O + O2 | - |
Homo sapiens | 2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-serine + H2O + O2 | low catalytic efficiency and substrate affinity on the physiological substrate D-serine | Homo sapiens | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-tryptophan + H2O + O2 | - |
Homo sapiens | indol-3-pyruvic acid + NH3 + H2O2 | - |
? | |
1.4.3.3 | D-tyrosine + H2O + O2 | - |
Homo sapiens | 4-hydroxyphenylpyruvic acid + NH3 + H2O2 | - |
? | |
1.4.3.3 | glycine + H2O + O2 | - |
Homo sapiens | glyoxylate + NH3 + H2O2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.4.3.3 | homodimer | - |
Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.4.3.3 | D-amino acid oxidase | - |
Homo sapiens |
1.4.3.3 | DAAO | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.3.3 | 0.9 | - |
glycine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 3 | - |
D-serine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 3.2 | - |
D-tryptophan | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 5.2 | - |
D-alanine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 6.6 | - |
D-phenylalanine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 6.7 | - |
D-Aspartate | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 10.2 | - |
D-proline | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 14.8 | - |
D-tyrosine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 21.7 | - |
D-Dopa | at pH 7.0 and 25°C | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.4.3.3 | FAD | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.3.3 | 0.007 | - |
benzoate | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 0.7 | - |
chlorpromazine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 0.7 | - |
trifluoro-D-alanine | at pH 7.0 and 25°C | Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.4.3.3 | 0.000004 | - |
at pH 7.0 and 25°C | Homo sapiens | 3-hydroxyquinoline-2-(1H)-one | |
1.4.3.3 | 0.000141 | - |
at pH 7.0 and 25°C | Homo sapiens | 4H-furo[3,2-b]pyrrole-5-carboxylic acid | |
1.4.3.3 | 0.000145 | - |
at pH 7.0 and 25°C | Homo sapiens | 4H-thieno[3,2-b]pyrrole-5-carboxylic acid | |
1.4.3.3 | 0.00018 | - |
at pH 7.0 and 25°C | Homo sapiens | 6-chlorobenzo[d]isoxazol-3-ol | |
1.4.3.3 | 0.00091 | - |
at pH 7.0 and 25°C | Homo sapiens | 5-methylpyrazole-3-carboxylic acid |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.4.3.3 | malfunction | a total loss of enzymatic activity is associated with the adult onset of familial amyotrophic lateral sclerosis. Altered enzyme expression levels and activity have been reported in schizophrenia | Homo sapiens |
1.4.3.3 | physiological function | the enzyme is part responsible for the significant increases in brain kynurenic acid levels seen under inflammatory conditions | Homo sapiens |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.3.3 | 0.003 | - |
D-Aspartate | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 0.005 | - |
glycine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 0.4 | - |
D-serine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 1.3 | - |
D-proline | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 2.1 | - |
D-tryptophan | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 2.4 | - |
D-phenylalanine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 4 | - |
D-alanine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 9.9 | - |
D-tyrosine | at pH 7.0 and 25°C | Homo sapiens | |
1.4.3.3 | 14.5 | - |
D-Dopa | at pH 7.0 and 25°C | Homo sapiens |