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Literature summary extracted from

  • Subathra, M.; Qureshi, A.; Luberto, C.
    Sphingomyelin synthases regulate protein trafficking and secretion (2011), PLoS ONE, 6, e23644.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.27 D609
-
 Homo sapiens
2.7.8.27 D609
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.27 Golgi apparatus isoform SMS1 and SMS2 Homo sapiens 5794
-
2.7.8.27 Golgi apparatus isoform SMS1 and SMS2 Rattus norvegicus 5794
-
2.7.8.27 plasma membrane isoform SMS2 Homo sapiens 5886
-
2.7.8.27 plasma membrane isoform SMS2 Rattus norvegicus 5886
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.27 Homo sapiens
-
-
-
2.7.8.27 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.27 INS-1 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.27 phosphatidylcholine + ceramide
-
 Homo sapiens sphingomyelin + 1,2-diacyl-sn-glycerol
-
 ?
2.7.8.27 phosphatidylcholine + ceramide
-
 Rattus norvegicus sphingomyelin + 1,2-diacyl-sn-glycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.27 SMS1 isoform Homo sapiens
2.7.8.27 SMS1 isoform Rattus norvegicus
2.7.8.27 SMS2 isoform Homo sapiens
2.7.8.27 SMS2 isoform Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.7.8.27 malfunction down-regulation of isoform SMS1 and SMS2 reduces the localization of the DAG-binding protein, protein kinase D to the Golgi Homo sapiens
2.7.8.27 malfunction down-regulation of isoform SMS1 and SMS2 reduces the localization of the DAG-binding protein, protein kinase D to the Golgi. Inhibition of the enzyme significantly reduces insulin secretion in rat INS-1 cells Rattus norvegicus
2.7.8.27 physiological function isoform SMS1 and SMS2 are capable of regulating trans golgi network-mediated protein trafficking and secretion. Both isoform activities are critical to retain the correct morphology of both cis-Golgi and trans golgi network Homo sapiens
2.7.8.27 physiological function isoform SMS1 and SMS2 are capable of regulating trans golgi network-mediated protein trafficking and secretion. Both isoform activities are critical to retain the correct morphology of both cis-Golgi and trans-Golgi network Rattus norvegicus