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Literature summary extracted from

  • Hara, N.; Yamada, K.; Shibata, T.; Osago, H.; Tsuchiya, M.
    Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma (2011), PLoS ONE, 6, e22781.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.12 ATP essential activator Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.12
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.12 0.00051
-
 5-phosphoribosyl 1-diphosphate with 1 mM ATP, pH 7.5, 37°C Homo sapiens
2.4.2.12 0.00122
-
 nicotinamide with 1 mM ATP, pH 7.5, 37°C Homo sapiens
2.4.2.12 0.00806
-
 nicotinamide without ATP, pH 7.5, 37°C Homo sapiens
2.4.2.12 0.0232
-
 5-phosphoribosyl 1-diphosphate without ATP, pH 7.5, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.12 0.00213
-
 at 0.001 mM 5-phosphoribosyl 1-diphosphate, without ATP, pH 7.5, 37°C Homo sapiens
2.4.2.12 0.0259
-
 at 0.050 mM 5-phosphoribosyl 1-diphosphate, without ATP, pH 7.5, 37°C Homo sapiens
2.4.2.12 0.0259
-
 substrate 5-phosphoribosyl 1-diphosphate, without ATP, pH 7.5, 37°C Homo sapiens
2.4.2.12 0.0393
-
 substrate nicotinamide, without ATP, pH 7.5, 37°C Homo sapiens
2.4.2.12 0.0397
-
 substrate nicotinamide, with 1 mM ATP, pH 7.5, 37°C Homo sapiens
2.4.2.12 0.0481
-
 at 0.050 mM 5-phosphoribosyl 1-diphosphate, with 1 mM ATP, pH 7.5, 37°C Homo sapiens
2.4.2.12 0.0704
-
 at 0.001 mM 5-phosphoribosyl 1-diphosphate, with 1 mM ATP, pH 7.5, 37°C Homo sapiens
2.4.2.12 0.0741
-
 substrate 5-phosphoribosyl 1-diphosphate, with 1 mM ATP, pH 7.5, 37°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phosphoribosyl 1-diphosphate
-
 Homo sapiens nicotinamide mononucleotide + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 nicotinamide phosphoribosyltransferase
-
 Homo sapiens
2.4.2.12 nicotinamide phosphoribosyltransferase/Visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma Homo sapiens