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Literature summary extracted from

  • Grossmann, K.; Hutzler, J.; Tresch, S.; Christiansen, N.; Looser, R.; Ehrhardt, T.
    On the mode of action of the herbicides cinmethylin and 5-benzyloxymethyl-1, 2-isoxazolines: putative inhibitors of plant tyrosine aminotransferase (2012), Pest Manag. Sci., 68, 482-492.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.5 recombinantly expressed in Escherichia coli as a His-tagged fusion protein Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.5 2-chloro-3-(5-{[(2,6-difluorobenzyl)oxy]methyl}-5-methyl-4,5-dihydro-1,2-oxazol-3-yl)-6-(propan-2-yl)pyridine 1 mM: 79% inhibition of enzyme activity, 0.5 mM: 67% inhibition of enzyme activity, 0.25 mM: 44% inhibition of enzyme activity Arabidopsis thaliana
2.6.1.5 3-(5-{[(2,6-difluorobenzyl)oxy]methyl}-5-methyl-4,5-dihydro-1,2-oxazol-3-yl)pyridine-2-carbonitrile 1 mM: 82% inhibition of enzyme activity, 0.5 mM: 46% inhibition of enzyme activity, 0.25 mM: 8% inhibition of enzyme activity Arabidopsis thaliana
2.6.1.5 cinmethylin 0.5 mM: 96% inhibition of enzyme activity, 0.25 mM: 20% inhibition of enzyme activity Arabidopsis thaliana
2.6.1.5 methiozolin 0.5 mM: 91% inhibition of enzyme activity, 0.25 mM: 57% inhibition of enzyme activity Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.5 Arabidopsis thaliana
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.5 using Ni-NTA chromatography Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.5 L-tyrosine + 2-oxoglutarate
-
 Arabidopsis thaliana 4-hydroxyphenylpyruvate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.5 TAT
-
 Arabidopsis thaliana

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.5 7.4
-
 assay at Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.5 pyridoxal 5'-phosphate
-
 Arabidopsis thaliana