EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.8.27 | D609 | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.8.27 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.8.27 | chronic myeloid leukemia cell | - |
Homo sapiens | - |
2.7.8.27 | HL-60 cell | - |
Homo sapiens | - |
2.7.8.27 | K-562 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.8.27 | phosphatidylcholine + ceramide | - |
Homo sapiens | sphingomyelin + 1,2-diacyl-sn-glycerol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.8.27 | SMS1 | - |
Homo sapiens |
2.7.8.27 | sphingomyelin synthase 1 | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.7.8.27 | Homo sapiens | enzyme inhibition or down-regulation of SMS1 expression by siRNA selectively inhibits the proliferation of Bcr-abl-positive cells | down |
2.7.8.27 | Homo sapiens | isoform SMS1 is highly elevated (approximately 10fold) in K-562 chronic myelogenous leukemia cells | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.8.27 | physiological function | the Sms1 gene is a downstream target of Bcr-abl, involved in sustaining cell proliferation of Bcr-abl-positive cells | Homo sapiens |