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Literature summary extracted from

  • Jenkins, C.M.; Yang, J.; Sims, H.F.; Gross, R.W.
    Reversible high affinity inhibition of phosphofructokinase-1 by acyl-CoA: a mechanism integrating glycolytic flux with lipid metabolism (2011), J. Biol. Chem., 286, 11937-11950.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.11 Arachidonoyl-CoA
-
 Oryctolagus cuniculus
2.7.1.11 linoleoyl-CoA
-
 Oryctolagus cuniculus
2.7.1.11 additional information acetyl-CoA, malonyl-CoA, palmitoylcarnitine, and palmitic acid in the presence of CoASH are without effect on enzyme activity Oryctolagus cuniculus
2.7.1.11 oleoyl-CoA
-
 Oryctolagus cuniculus
2.7.1.11 palmitoyl-CoA low micromolar inhibitor, MgAMP and MgADP but not MgATP protect the enzyme against inhibition by palmitoyl-CoA. Acyl-protein thioesterase-1 reverses palmitoyl-CoA-mediated enzyme inhibition Oryctolagus cuniculus
2.7.1.11 palmitoylcarnitine-CoA
-
 Oryctolagus cuniculus
2.7.1.11 S-hexadecyl-CoA
-
 Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.11 cytosol
-
 Oryctolagus cuniculus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.11 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.11 ammonium sulfate precipitation DEAE-Sephacel gel filtration and Bio-Gel filtration Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.11 muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.11 ATP + D-fructose 6-phosphate
-
 Oryctolagus cuniculus ADP + D-fructose 1,6-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.11 6-phosphofructo 1-kinase
-
 Oryctolagus cuniculus
2.7.1.11 PFK-1
-
 Oryctolagus cuniculus
2.7.1.11 phosphofructokinase-1
-
 Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.11 0.0015
-
 in 50 mM imidazole, pH 8.0, containing 50 mM KCl and 2 mM MgCl2, at 22°C Oryctolagus cuniculus palmitoyl-CoA

General Information

EC Number General Information Comment Organism
2.7.1.11 physiological function the enzyme catalyzes the first committed and rate-determining step of glycolysis and thus represents an essential metabolic control point or node for carbohydrate utilization Oryctolagus cuniculus