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Literature summary extracted from

  • Zhang, L.Q.; Heruth, D.P.; Ye, S.Q.
    Nicotinamide phosphoribosyltransferase in human diseases (2011), J. Bioanal. Biomed., 3, 13-25.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.12
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.12 H247A active site residue, no detectable activity Homo sapiens
2.4.2.12 H247E active site residue, low activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 FK-866 i.e. (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-phenylprop-2-enamide Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.12 55520
-
 2 * 55520, theoretic value Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens P43490
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.2.12 phosphoprotein autophosphorylation can increase the activity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 brain
-
 Homo sapiens
-
2.4.2.12 heart
-
 Homo sapiens
-
2.4.2.12 kidney
-
 Homo sapiens
-
2.4.2.12 liver
-
 Homo sapiens
-
2.4.2.12 lung
-
 Homo sapiens
-
2.4.2.12 lymphocyte
-
 Homo sapiens
-
2.4.2.12 pancreas
-
 Homo sapiens
-
2.4.2.12 placenta
-
 Homo sapiens
-
2.4.2.12 skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phosphoribosyl 1-diphosphate
-
 Homo sapiens nicotinamide mononucleotide + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.12 homodimer 2 * 55520, theoretic value Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 nicotinamide phosphoribosyltransferase
-
 Homo sapiens
2.4.2.12 pre-B-cell colony enhancing factor
-
 Homo sapiens
2.4.2.12 Visfatin
-
 Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.4.2.12 Homo sapiens theoretic value
-
 6.69

General Information

EC Number General Information Comment Organism
2.4.2.12 malfunction implicated in the pathogenesis of a number of human diseases or conditions such as acute lung injury, aging, atherosclerosis, cancer, diabetes, rheumatoid arthritis and sepsis Homo sapiens
2.4.2.12 physiological function growth factor, cytokine and nicotinamide phosphoribosyltransferase Homo sapiens