Literature summary extracted from

Freitag, A.; Galm, U.; Li, S.M.; Heide, L.
New aminocoumarin antibiotics from a cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes DS12.976 (2004), J. Antibiot., 57, 205-209.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.111	Streptomyces roseochromogenus subsp. oscitans	Q8GHB2	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.5.1.111	CloQ	-	Streptomyces roseochromogenus subsp. oscitans

General Information

EC Number	General Information	Comment	Organism
2.5.1.111	malfunction	cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes, which is blocked in the biosynthesis of the prenylated 4-hydroxybenzoic acid moiety of clorobiocin produces three new antibiotics, vanillobiocin, isovanillobiocin and declovanillobiocin. The isolated compounds are similar to clorobiocin, but contain vanillic acid as the acyl component instead of the prenylated 4-hydroxybenzoic acid present in clorobiocin. Isovanillobiocin differs from vanillobiocin by the position of the pyrrole unit attached to the sugar moiety of the antibiotic. Declovanillobiocin lacks the chlorine atom at the aminocoumarin ring. All three compounds have lower antibiotic activity against Bacillus subtilis than clorobiocin	Streptomyces roseochromogenus subsp. oscitans

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Release 2023.1 (January 2023)