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Literature summary extracted from

  • Malik, M.; Park, E.; Shin, J.
    omega-Transaminase-catalyzed kinetic resolution of chiral amines using l-threonine as an amino acceptor precursor (2012), Green Chem., 14, 2137-2140.
No PubMed abstract available

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.18 Aspergillus terreus
-
 enantioselectivity of the omega-TA from Aspergillus terreus is opposite to that from Ochrobactrum anthropi
-
2.6.1.18 Brucella anthropi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.18 1-phenylethanamine + 2-oxobutyrate enantioselectivity of the omega-TA from Aspergillus terreus is opposite to that from Ochrobactrum anthropi, D-homoalanine of more than 99% enantiomeric excess is formed in this coupled reaction Aspergillus terreus acetophenone + D-homoalanine
-
 ?
2.6.1.18 1-phenylethanamine + 2-oxobutyrate
-
 Brucella anthropi acetophenone + L-homoalanine
-
 ?
2.6.1.18 1-phenylethanamine + propanal 94% relative activity toward propanal compared to pyruvate. Propanal is an inefficient amino acceptor for the kinetic resolution: Enantiomeric excess of (R)-alpha-methylbenzylamine reaches more than 99% with pyruvate at 3 h, whereas enantiomeric excess is only 57% with propanal even after the reaction for 24 h Brucella anthropi ?
-
 ?
2.6.1.18 1-phenylethanamine + pyruvate relative activity toward pyruvate: 100% Aspergillus terreus acetophenone + alanine
-
 ?
2.6.1.18 1-phenylethanamine + pyruvate relative activity toward pyruvate: 100% Brucella anthropi acetophenone + alanine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.18 omega-TA
-
 Aspergillus terreus
2.6.1.18 omega-transaminase
-
 Aspergillus terreus
2.6.1.18 omega-transaminase
-
 Brucella anthropi

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.18 37
-
 assay at Aspergillus terreus
2.6.1.18 37
-
 assay at Brucella anthropi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.18 7.5
-
 assay at Aspergillus terreus
2.6.1.18 7.5
-
 assay at Brucella anthropi

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.18 pyridoxal 5'-phosphate
-
 Aspergillus terreus
2.6.1.18 pyridoxal 5'-phosphate
-
 Brucella anthropi