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Literature summary extracted from

  • Gallicchio, M.A.; Bach, L.A.
    Advanced glycation end products inhibit Na+ K+ ATPase in proximal tubule epithelial cells: role of cytosolic phospholipase A2alpha and phosphatidylinositol 4-phosphate 5-kinase gamma (2010), Biochim. Biophys. Acta, 1803, 919-930.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.68 advanced glycation end products may stimulate PIP5Kgamma to increase 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production, which may enhance adaptor protein complex 2 localisation to clathrin pits, increase clathrin pit formation, enhance renal Na+/K+ ATPase cargo recognition by adaptor protein complex 2 and/or stimulate cytosolic phospholipase A2 alpha activity Homo sapiens
2.7.1.68 advanced glycation end products may stimulate PIP5Kgamma to increase 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production, which may enhance adaptor protein complex 2 localisation to clathrin pits, increase clathrin pit formation, enhance renal Na+/K+ ATPase cargo recognition by adaptor protein complex 2 and/or stimulate cytosolic phospholipase A2 alpha activity Sus scrofa

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.68 additional information PIP5Kgamma isozyme knockout by siRNA. Transfection of HK2 cells with PIP5Kgamma siRNA prevents advanced glycation end products-bovine serum albumin inhibition of renal Na+/K+ ATPase activity Homo sapiens
2.7.1.68 additional information PIP5Kgamma isozyme knockout by siRNA. Transfection of HK2 cells with PIP5Kgamma siRNA prevents advanced glycation end products-bovine serum albumin inhibition of renal Na+/K+ ATPase activity Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.68 Mg2+ required Homo sapiens
2.7.1.68 Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Sus scrofa
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.68 Homo sapiens
-
-
-
2.7.1.68 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.68 epithelial cell
-
 Homo sapiens
-
2.7.1.68 HK-2 cell
-
 Homo sapiens
-
2.7.1.68 LLC-PK1 cell
-
 Sus scrofa
-
2.7.1.68 proximale tubular epithelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Sus scrofa ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.68 phosphatidylinositol 4-phosphate 5-kinase gamma
-
 Homo sapiens
2.7.1.68 phosphatidylinositol 4-phosphate 5-kinase gamma
-
 Sus scrofa
2.7.1.68 PIP5Kgamma
-
 Homo sapiens
2.7.1.68 PIP5Kgamma
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.68 ATP
-
 Homo sapiens
2.7.1.68 ATP
-
 Sus scrofa

General Information

EC Number General Information Comment Organism
2.7.1.68 physiological function phosphatidylinositol 4,5 bisphosphate is a major membrane phospholipid that affects cellular processes such as actin cytoskeleton modulation, membrane trafficking and ion channel activity. Isozyme PIP5Kgamma is essential for advanced glycation end products induced inhibition of renal Na+/K+ ATPase activity Homo sapiens
2.7.1.68 physiological function phosphatidylinositol 4,5 bisphosphate is a major membrane phospholipid that affects cellular processes such as actin cytoskeleton modulation, membrane trafficking and ion channel activity. Isozyme PIP5Kgamma is essential for advanced glycation end products induced inhibition of renal Na+/K+ ATPase activity Sus scrofa