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Literature summary extracted from

  • Kumar, D.; Palaniyandi, K.; Challu, V.; Kumar, P.; Narayanan, S.
    PknE, a serine/threonine protein kinase from Mycobacterium tuberculosis has a role in adaptive responses (2013), Arch. Microbiol., 195, 75-80.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.1 additional information generation of the enzyme-deletion mutant DELTApknE. Mutant DELTApknE in presence of stress (pH, surfactant and cell wall-damaging agents) and anti-tuberculosis drugs shows defective growth in pH 7.0 and lysozyme with better survival in pH 5.5, SDS, and kanamycin. DELTApknE is resistant to kanamycin Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Mycobacterium tuberculosis P9WI77 gene pknE
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2.7.11.1 Mycobacterium tuberculosis H37Rv P9WI77 gene pknE
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Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 PknE
-
 Mycobacterium tuberculosis
2.7.11.1 serine/threonine protein kinase
-
 Mycobacterium tuberculosis
2.7.11.1 StpK
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.7.11.1 malfunction the enzyme-deletion mutant DELTApknE shows in presence of stress (pH, surfactant and cell wall-damaging agents) and anti-tuberculosis drugs a defective growth in pH 7.0 and lysozyme (a cell wall-damaging agent) with better survival in pH 5.5, SDS, and kanamycin (a second-line anti-tuberculosis drug). DELTApknE is reduced in cell size during growth in liquid media and exhibits hypervirulence in a guinea pig model of infection Mycobacterium tuberculosis
2.7.11.1 physiological function the enzyme is involved in the adaptive responses and contributes to the suppression of apoptosis Mycobacterium tuberculosis