EC Number | Cloned (Comment) | Organism |
---|---|---|
2.6.1.64 | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.64 | CH3-S-Hg-homocysteine | 50% inhibition at 0.5 mM | Homo sapiens | |
2.6.1.64 | CH3Hg-S-Cys | substrate and reversible inhibitor, 50% inhibition at 0.5 mM | Homo sapiens | |
2.6.1.64 | Cys-S-Hg-S-Cys | substrate and reversible inhibitor, 37% inhibition at 0.5 mM | Homo sapiens | |
2.6.1.64 | homocysteine-S-Hg-S-homocysteine | 67% inhibition at 1 mM | Homo sapiens | |
4.4.1.1 | 4-chloromercuribenzoate | - |
Rattus norvegicus | |
4.4.1.1 | CH3-Hg-S-Cys | the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor | Rattus norvegicus | |
4.4.1.1 | Cys-S-Hg-S-Cys | the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor | Rattus norvegicus | |
4.4.1.1 | HgCl2 | a potent irreversible enzyme inhibitor, but HgCl2 is also a strong inactivator of cystathionine gamma-lyase | Rattus norvegicus | |
4.4.1.1 | Iodosobenzoate | - |
Rattus norvegicus | |
4.4.1.1 | additional information | extent to which inactivation occurs with the various mercury-containing compounds in descending order: Cys-S-Hg-S-Cys, HgCl2, CH3Hg-S-Cys | Rattus norvegicus | |
4.4.1.1 | N-ethylmaleimide | - |
Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
4.4.1.1 | HgCl2 | a potent irreversible enzyme inhibitor, but HgCl2 is also a strong inactivator of cystathionine gamma-lyase | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.4.1.1 | L-cystathionine + H2O | Rattus norvegicus | - |
2-oxobutyrate + L-cysteine + NH3 | - |
? | |
4.4.1.1 | L-cystine + H2O | Rattus norvegicus | - |
pyruvate + NH3 + L-thiocysteine | - |
? | |
4.4.1.1 | L-homoserine | Rattus norvegicus | the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term | 2-oxobutyrate + NH3 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.64 | Homo sapiens | - |
- |
- |
4.4.1.1 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.4.1.1 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
4.4.1.1 | 24 | - |
purified liver enzyme, pH 7.4, 37°C | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.64 | CH3Hg-S-Cys + phenylpyruvate | - |
Homo sapiens | ? + L-phenylalanine | - |
? | |
2.6.1.64 | Cys-S-Hg-S-Cys + phenylpyruvate | - |
Homo sapiens | ? + L-phenylalanine | - |
? | |
2.6.1.64 | L-cystathionine + phenylpyruvate | - |
Homo sapiens | S-(2-oxo-2-carboxyethyl)homocysteine + L-phenylalanine | - |
? | |
2.6.1.64 | L-cysteine + phenylpyruvate | - |
Homo sapiens | 3-mercapto-2-oxopropanoate + L-phenylalanine | - |
? | |
2.6.1.64 | L-methionine + phenylpyruvate | - |
Homo sapiens | 4-methylsulfanyl-2-oxobutanoate + L-phenylalanine | - |
? | |
4.4.1.1 | L-cystathionine + H2O | - |
Rattus norvegicus | 2-oxobutyrate + L-cysteine + NH3 | - |
? | |
4.4.1.1 | L-cystine + H2O | - |
Rattus norvegicus | pyruvate + NH3 + L-thiocysteine | - |
? | |
4.4.1.1 | L-homoserine | the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term | Rattus norvegicus | 2-oxobutyrate + NH3 | - |
? | |
4.4.1.1 | additional information | no activity with L-methionine | Rattus norvegicus | ? | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.4.1.1 | 37 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.4.1.1 | 7.4 | - |
assay at | Rattus norvegicus |