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Literature summary extracted from

  • Pak, V.V.; Koo, M.; Kwon, D.Y.; Yun, L.
    Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase (2012), Amino Acids, 43, 2015-2025.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 AFGYVAE
-
 Homo sapiens
1.1.1.34 DFGYVAE
-
 Homo sapiens
1.1.1.34 EFGYVAE
-
 Homo sapiens
1.1.1.34 FFGYVAE
-
 Homo sapiens
1.1.1.34 FFYVAE
-
 Homo sapiens
1.1.1.34 FG-(4-fluoro)FVAE
-
 Homo sapiens
1.1.1.34 FGYVAE
-
 Homo sapiens
1.1.1.34 FPYVAE
-
 Homo sapiens
1.1.1.34 GFGYVAE
-
 Homo sapiens
1.1.1.34 IAVPTGVA
-
 Homo sapiens
1.1.1.34 IFGYVAE
-
 Homo sapiens
1.1.1.34 Ile-Ala-Val-Glu
-
 Homo sapiens
1.1.1.34 Ile-Ala-Val-Pro-Gly-Glu-Val-Ala
-
 Homo sapiens
1.1.1.34 Ile-Val-Ala-Glu
-
 Homo sapiens
1.1.1.34 Leu-Pro-Tyr-Pro
-
 Homo sapiens
1.1.1.34 LFGYVAE
-
 Homo sapiens
1.1.1.34 additional information design of highly potent and competitive inhibitory peptides for 3-hydroxy-3-methylglutaryl CoA reductase, no inhibition with SFGYVAG peptide Homo sapiens
1.1.1.34 PFGYVAE
-
 Homo sapiens
1.1.1.34 SFGYVAE peptide most active inhibitory peptide; shows high ability to inhibit HMGR by competitive inhibition with respect to (S)-3-hydroxy-3-methylglutaryl-CoA Homo sapiens
1.1.1.34 TFGYVAE
-
 Homo sapiens
1.1.1.34 Tyr-Ala-Val-Glu
-
 Homo sapiens
1.1.1.34 Tyr-Val-Ala-Glu
-
 Homo sapiens
1.1.1.34 VFGYVAE
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Homo sapiens
-
 (R)-mevalonate + CoA + 2 NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Homo sapiens (R)-mevalonate + CoA + 2 NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 3-hydroxy-3-methylglutaryl CoA reductase
-
 Homo sapiens
1.1.1.34 HMG-CoA reductase
-
 Homo sapiens
1.1.1.34 HMGR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.34 0.000012
-
 SFGYVAE peptide pH and temperature not specified in the publication Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.34 0.000033
-
 pH and temperature not specified in the publication Homo sapiens SFGYVAE peptide
1.1.1.34 0.00016
-
 pH and temperature not specified in the publication Homo sapiens DFGYVAE
1.1.1.34 0.00024
-
 pH and temperature not specified in the publication Homo sapiens EFGYVAE
1.1.1.34 0.00026
-
 pH and temperature not specified in the publication Homo sapiens TFGYVAE
1.1.1.34 0.00027
-
 pH and temperature not specified in the publication Homo sapiens GFGYVAE
1.1.1.34 0.00032
-
 pH and temperature not specified in the publication Homo sapiens FFGYVAE
1.1.1.34 0.00035
-
 pH and temperature not specified in the publication Homo sapiens IFGYVAE
1.1.1.34 0.00037
-
 pH and temperature not specified in the publication Homo sapiens LFGYVAE
1.1.1.34 0.0004
-
 pH and temperature not specified in the publication Homo sapiens FGYVAE
1.1.1.34 0.00043
-
 pH and temperature not specified in the publication Homo sapiens PFGYVAE
1.1.1.34 0.00045
-
 pH and temperature not specified in the publication Homo sapiens VFGYVAE
1.1.1.34 0.00049
-
 pH and temperature not specified in the publication Homo sapiens AFGYVAE
1.1.1.34 0.0014
-
 pH and temperature not specified in the publication Homo sapiens FPYVAE
1.1.1.34 0.0025
-
 pH and temperature not specified in the publication Homo sapiens FFYVAE
1.1.1.34 0.0085
-
 pH and temperature not specified in the publication Homo sapiens FG-(4-fluoro)FVAE
1.1.1.34 0.041
-
 pH and temperature not specified in the publication Homo sapiens Tyr-Val-Ala-Glu
1.1.1.34 0.044
-
 pH and temperature not specified in the publication Homo sapiens Tyr-Ala-Val-Glu
1.1.1.34 0.052
-
 pH and temperature not specified in the publication Homo sapiens Ile-Val-Ala-Glu
1.1.1.34 0.075
-
 pH and temperature not specified in the publication Homo sapiens Ile-Ala-Val-Glu
1.1.1.34 0.152
-
 pH and temperature not specified in the publication Homo sapiens IAVPTGVA
1.1.1.34 0.201
-
 pH and temperature not specified in the publication Homo sapiens Ile-Ala-Val-Pro-Gly-Glu-Val-Ala
1.1.1.34 0.484
-
 pH and temperature not specified in the publication Homo sapiens Leu-Pro-Tyr-Pro

General Information

EC Number General Information Comment Organism
1.1.1.34 physiological function the enzyme is the major regulatory enzyme of cholesterol biosynthesis and the target enzyme of many investigations aimed at lowering the rate of cholesterol biosynthesis Homo sapiens