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Literature summary extracted from

  • Janowski, R.; Kefala, G.; Weiss, M.S.
    The structure of dihydrodipicolinate reductase (DapB) from Mycobacterium tuberculosis in three crystal forms (2010), Acta Crystallogr. Sect. D, 66, 61-72.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.1.8
-
 Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.17.1.8 in complex with NADH Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.1.8 0.0032
-
 NADH pH and temperature not specified in the publication Mycobacterium tuberculosis
1.17.1.8 0.0118
-
 NADPH pH and temperature not specified in the publication Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.8 Mycobacterium tuberculosis P9WP23
-
-
1.17.1.8 Mycobacterium tuberculosis H37Rv P9WP23
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.1.8
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+
-
 Mycobacterium tuberculosis (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O
-
 ir
1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+
-
 Mycobacterium tuberculosis H37Rv (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O
-
 ir
1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+
-
 Mycobacterium tuberculosis (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O
-
 ir
1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+
-
 Mycobacterium tuberculosis H37Rv (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O
-
 ir

Subunits

EC Number Subunits Comment Organism
1.17.1.8 tetramer x-ray crystallography Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
1.17.1.8 DapB
-
 Mycobacterium tuberculosis
1.17.1.8 DHDPR
-
 Mycobacterium tuberculosis
1.17.1.8 dihydrodipicolinate reductase
-
 Mycobacterium tuberculosis
1.17.1.8 EC 1.3.1.26 formerly Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.8 NADH
-
 Mycobacterium tuberculosis
1.17.1.8 NADPH
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
1.17.1.8 metabolism the enzyme belongs to the L-lysine biosynthetic pathway Mycobacterium tuberculosis