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Literature summary extracted from

  • Brahmajosyula, M.; Miyake, M.
    Localization and expression of peptidylarginine deiminase 4 (PAD4) in mammalian oocytes and preimplantation embryos (2013), Zygote, 21, 314-324.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.3.15 cytoplasm
-
 Mus musculus 5737
-
3.5.3.15 cytoplasm PAD4 primarily localizes in the cytoplasm in pig oocytes and parthenogenetic embryos Sus scrofa 5737
-
3.5.3.15 nucleus in mouse in vitro fertilized embryos, nuclear translocation starts from the 2-cell stage and gradually increases up to blastocyst Mus musculus 5634
-
3.5.3.15 nucleus nuclear translocation of PAD4 is observed in late germinal vesicle stage oocytes prior to germinal vesicle breakdown and is localized around the metaphase (M)I and II spindle. Nucleus-localized PAD4 is noticed partially in blastocysts Sus scrofa 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.15 Mus musculus
-
-
-
3.5.3.15 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.15 blastocyst
-
 Sus scrofa
-
3.5.3.15 embryo
-
 Mus musculus
-
3.5.3.15 embryo
-
 Sus scrofa
-
3.5.3.15 oocyte
-
 Sus scrofa
-

Synonyms

EC Number Synonyms Comment Organism
3.5.3.15 PAD4
-
 Mus musculus
3.5.3.15 PAD4
-
 Sus scrofa

General Information

EC Number General Information Comment Organism
3.5.3.15 physiological function the target of citrullination is histone protein (H3), not B23. Therefore the presence of PAD4 and citrullinated histone H3 in oocytes and embryos suggests a possible role for PAD4 in preimplantation embryonic development Mus musculus
3.5.3.15 physiological function the target of citrullination is histone protein (H3), not B23. Therefore the presence of PAD4 and citrullinated histone H3 in oocytes and embryos suggests a possible role for PAD4 in preimplantation embryonic development Sus scrofa