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Literature summary extracted from

  • Gerber, A.P.; Keller, W.
    An adenosine deaminase that generates inosine at the wobble position of tRNAs (1999), Science, 286, 1146-1149.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.5.4.33 E56A mutation in subunit Tad2, mutant enzyme has no deaminase activity in vitro Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.33 adenine34 in tRNA + H2O Saccharomyces cerevisiae
-
hypoxanthine34 in tRNA + NH3
-
?
3.5.4.33 adenine34 in tRNA + H2O Saccharomyces cerevisiae ATCC 204508
-
hypoxanthine34 in tRNA + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.33 Saccharomyces cerevisiae P47058 and Q9URQ3 P47058: TAD2 and Q9URQ3: TAD3
-
3.5.4.33 Saccharomyces cerevisiae ATCC 204508 P47058 and Q9URQ3 P47058: TAD2 and Q9URQ3: TAD3
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.33 adenine34 in tRNA + H2O
-
Saccharomyces cerevisiae hypoxanthine34 in tRNA + NH3
-
?
3.5.4.33 adenine34 in tRNA + H2O
-
Saccharomyces cerevisiae ATCC 204508 hypoxanthine34 in tRNA + NH3
-
?

Subunits

EC Number Subunits Comment Organism
3.5.4.33 dimer the heterodimeric enzyme consists of two sequence-related subunits (Tad2p/ADAT2 and Tad3p/ADAT3), both of which contain cytidine deaminase motifs Saccharomyces cerevisiae