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Literature summary extracted from

  • Li, C.; Guan, Z.; Liu, D.; Raetz, C.R.
    Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli (2011), Proc. Natl. Acad. Sci. USA, 108, 11387-11392.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.129 gene lpxA, five AtLpxC orthologues located in a 68-kb region on chromosome one, DNA and amino acid sequence determination and analysis, sequence comparison Arabidopsis thaliana
2.3.1.191 gene AtlpxD, two AtLpxD isozymes, AtLxpD1 and AtLpxD2, are encoded on chromosome 4, DNA and amino acid sequence determination and analysis, expression as GFP-tagged protein in Arabidopsis thaliana Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.191 additional information construction of lpx insertional knockout mutations or RNAi knock-down mutants Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.129 mitochondrion
-
 Arabidopsis thaliana 5739
-
2.3.1.191 mitochondrion LpxD proteins in Arabidopsis thaliana are targeted to the mitochondria, subcellular localization analysis, overview Arabidopsis thaliana 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.129 an (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine Arabidopsis thaliana
-
 an [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine
-
 r
2.3.1.191 (3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine Arabidopsis thaliana
-
 UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
 ir
2.3.1.191 (3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine Arabidopsis thaliana Col-0
-
 UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.129 Arabidopsis thaliana Q9SU91 gene lpxA, isozymes LpxA1 and LpxA2
-
2.3.1.191 Arabidopsis thaliana F4JGP6 AtlpxD1; gene AtlpxD1
-
2.3.1.191 Arabidopsis thaliana Col-0 F4JGP6 AtlpxD1; gene AtlpxD1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.129 seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.129 an (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Arabidopsis thaliana an [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine
-
 r
2.3.1.191 (3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine
-
 Arabidopsis thaliana UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
 ir
2.3.1.191 (3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine
-
 Arabidopsis thaliana Col-0 UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
 ir

Synonyms

EC Number Synonyms Comment Organism
2.3.1.129 LpxA
-
 Arabidopsis thaliana
2.3.1.191 LpxD
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.3.1.129 metabolism LpxA catalyzes the first step in lipid A biosynthesis, pathway overview Arabidopsis thaliana
2.3.1.191 metabolism the enzyme is involved in the lipid A biosynthesis in the plant Arabidopsis thaliana