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Literature summary extracted from

  • May, J.F.; Splain, R.A.; Brotschi, C.; Kiessling, L.L.
    A tethering mechanism for length control in a processive carbohydrate polymerization (2009), Proc. Natl. Acad. Sci. USA, 106, 11851-11856.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.288 expressed in Escherichia coli Tuner (DE3) cells Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.288 Mycobacterium tuberculosis
-
-
-
2.4.1.288 Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.288 HisTrap column chromatography, gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.288 additional information GlfT2 mediates synthesis of the galactan polymer, which contains between 20 and 40 D-galactofuranose residues connected by alternating beta-D-galactofuranosyl-(1->5)-D-galactofuranose and beta-D-galactofuranosyl-(1->6)-D-galactofuranose linkages. Elongation occurs by addition of D-galactofuranose residues from UDP-alpha-D-galactofuranose to the nonreducing end of a lipid-linked acceptor Mycobacterium tuberculosis ?
-
 ?
2.4.1.288 additional information no activity with 4-phenoxy-but-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside Mycobacterium tuberculosis ?
-
 ?
2.4.1.288 additional information GlfT2 mediates synthesis of the galactan polymer, which contains between 20 and 40 D-galactofuranose residues connected by alternating beta-D-galactofuranosyl-(1->5)-D-galactofuranose and beta-D-galactofuranosyl-(1->6)-D-galactofuranose linkages. Elongation occurs by addition of D-galactofuranose residues from UDP-alpha-D-galactofuranose to the nonreducing end of a lipid-linked acceptor Mycobacterium tuberculosis H37Rv ?
-
 ?
2.4.1.288 additional information no activity with 4-phenoxy-but-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside Mycobacterium tuberculosis H37Rv ?
-
 ?
2.4.1.288 UDP-alpha-D-galactofuranose + 12-phenoxy-dodec-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside the enzyme functions as a processive polymerase only with 12-phenoxy-dodec-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside Mycobacterium tuberculosis UDP + ?
-
 ?
2.4.1.288 UDP-alpha-D-galactofuranose + 12-phenoxy-dodec-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside the enzyme functions as a processive polymerase only with 12-phenoxy-dodec-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside Mycobacterium tuberculosis H37Rv UDP + ?
-
 ?
2.4.1.288 UDP-alpha-D-galactofuranose + 19-phenoxy-nondec-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside
-
 Mycobacterium tuberculosis UDP + ?
-
 ?
2.4.1.288 UDP-alpha-D-galactofuranose + 19-phenoxy-nondec-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside
-
 Mycobacterium tuberculosis H37Rv UDP + ?
-
 ?
2.4.1.288 UDP-alpha-D-galactofuranose + 9-phenoxy-non-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside
-
 Mycobacterium tuberculosis UDP + ?
-
 ?
2.4.1.288 UDP-alpha-D-galactofuranose + 9-phenoxy-non-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside
-
 Mycobacterium tuberculosis H37Rv UDP + ?
-
 ?
2.4.1.288 UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
-
 Mycobacterium tuberculosis UDP + [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
-
 ?
2.4.1.288 UDP-alpha-D-galactofuranose + dec-2-enyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranoside
-
 Mycobacterium tuberculosis UDP + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.288 galactofuranosyltransferase
-
 Mycobacterium tuberculosis
2.4.1.288 GlfT2
-
 Mycobacterium tuberculosis
2.4.1.288 Rv3808c
-
 Mycobacterium tuberculosis