EC Number | General Stability | Organism |
---|---|---|
2.1.1.45 | treatment of zebrafish embryos with 5-fluorouracil increases the enzyme stability significantly, the half life of enzyme protein is about 2.7 times longer than in untreated embryos | Danio rerio |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.45 | Danio rerio | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.45 | embryo | - |
Danio rerio | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Danio rerio | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | additional information | the enzyme is specifically bound with its cognate mRNA in vitro and in vivo | Danio rerio | ? | - |
? |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.1.1.45 | Danio rerio | the expression of thymidylate synthase is increased by about 6fold when embryos are treated with 0.001 mM 5-fluorouracil and there is a greater than 10fold increase in the enzyme protein level after treatment with 0.0004 mM ZD1694 | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.45 | physiological function | the enzyme is indispensable for DNA replication in actively dividing cells | Danio rerio |