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Literature summary extracted from

  • Li, S.M.; Unsoeld, I.A.
    Post-genome research on the biosynthesis of ergot alkaloids (2006), Planta Med., 72, 1117-1120.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.100 gene fgaPT1, DNA and amino acid sequence determination and analysis, genetic organization, phylogenetic analysis Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.100 fumigaclavine A + dimethylallyl diphosphate Aspergillus fumigatus
-
 fumigaclavine C + diphosphate
-
 ?
2.5.1.100 fumigaclavine A + dimethylallyl diphosphate Aspergillus fumigatus Af293
-
 fumigaclavine C + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.100 Aspergillus fumigatus
-
 gene fgaPT1, in the gene cluster of fumigaclabvine C biosynthesis
-
2.5.1.100 Aspergillus fumigatus Af293
-
 gene fgaPT1, in the gene cluster of fumigaclabvine C biosynthesis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.100 fumigaclavine A + dimethylallyl diphosphate
-
 Aspergillus fumigatus fumigaclavine C + diphosphate
-
 ?
2.5.1.100 fumigaclavine A + dimethylallyl diphosphate
-
 Aspergillus fumigatus Af293 fumigaclavine C + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.100 FgaPT1
-
 Aspergillus fumigatus

General Information

EC Number General Information Comment Organism
2.5.1.100 metabolism FgaPT1 catalyzes the last step of fumigaclavine C biosynthesis, i.e. the prenylation of fumigaclavine A at C-2 position of the indole nucleus, which is included in the biosynthesis of ergot alkaloids Aspergillus fumigatus