Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Monshupanee, T.; Johansen, S.K.; Dahlberg, A.E.; Douthwaite, S.
    Capreomycin susceptibility is increased by TlyA-directed 2-O-methylation on both ribosomal subunits (2012), Mol. Microbiol., 85, 1194-1203.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.226 gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1 Thermus thermophilus
2.1.1.226 gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1 Geobacillus stearothermophilus
2.1.1.226 gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1 Mycobacterium tuberculosis
2.1.1.226 gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1 Streptomyces coelicolor
2.1.1.226 gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1 Mycolicibacterium smegmatis
2.1.1.226 gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1 Brachyspira hyodysenteriae
2.1.1.227 gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1 Geobacillus stearothermophilus
2.1.1.227 gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1 Mycobacterium tuberculosis
2.1.1.227 gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1 Streptomyces coelicolor
2.1.1.227 gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1 Mycolicibacterium smegmatis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.226 Mg2+ required Thermus thermophilus
2.1.1.226 Mg2+ required Geobacillus stearothermophilus
2.1.1.226 Mg2+ required Mycobacterium tuberculosis
2.1.1.226 Mg2+ required Streptomyces coelicolor
2.1.1.226 Mg2+ required Mycolicibacterium smegmatis
2.1.1.226 Mg2+ required Brachyspira hyodysenteriae
2.1.1.227 Mg2+ required Geobacillus stearothermophilus
2.1.1.227 Mg2+ required Mycobacterium tuberculosis
2.1.1.227 Mg2+ required Streptomyces coelicolor
2.1.1.227 Mg2+ required Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA Geobacillus stearothermophilus
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA Mycobacterium tuberculosis
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA Streptomyces coelicolor
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA Mycolicibacterium smegmatis
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA Thermus thermophilus the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA Brachyspira hyodysenteriae
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA Brachyspira hyodysenteriae the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA Mycobacterium tuberculosis H37Rv
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA Mycolicibacterium smegmatis mc(2)155
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA Thermus thermophilus HB8 / ATCC 27634 / DSM 579 the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 16S rRNA Geobacillus stearothermophilus
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
 ?
2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 16S rRNA Mycobacterium tuberculosis
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
 ?
2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 16S rRNA Streptomyces coelicolor
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
 ?
2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 16S rRNA Mycobacterium tuberculosis H37Rv
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.226 Brachyspira hyodysenteriae Q06803 gene tlyA
-
2.1.1.226 Geobacillus stearothermophilus
-
 gene tlyA
-
2.1.1.226 Mycobacterium tuberculosis
-
 gene tlyA
-
2.1.1.226 Mycobacterium tuberculosis H37Rv
-
 gene tlyA
-
2.1.1.226 Mycolicibacterium smegmatis A0QYR0 gene tlyA
-
2.1.1.226 Mycolicibacterium smegmatis mc(2)155 A0QYR0 gene tlyA
-
2.1.1.226 no activity in Escherichia coli
-
-
-
2.1.1.226 Streptomyces coelicolor
-
 gene tlyA
-
2.1.1.226 Thermus thermophilus
-
 gene tlyA
-
2.1.1.226 Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
 gene tlyA
-
2.1.1.227 Geobacillus stearothermophilus
-
 gene tlyA
-
2.1.1.227 Mycobacterium tuberculosis
-
 gene tlyA
-
2.1.1.227 Mycobacterium tuberculosis H37Rv
-
 gene tlyA
-
2.1.1.227 Mycolicibacterium smegmatis A0QYR0 gene tlyA
-
2.1.1.227 Mycolicibacterium smegmatis mc(2)155 A0QYR0 gene tlyA
-
2.1.1.227 no activity in Escherichia coli
-
-
-
2.1.1.227 Streptomyces coelicolor
-
 gene tlyA
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.226 additional information the TlyAII enzyme methylates efficiently at C1920 in 50S subunits in vitro, although weaker activity is also detected on 70S ribosome and 23S rRNA substrates Mycolicibacterium smegmatis ?
-
 ?
2.1.1.226 additional information the TlyAII enzyme methylates efficiently at C1920 in 50S subunits in vitro, although weaker activity is also detected on 70S ribosome and 23S rRNA substrates Mycolicibacterium smegmatis mc(2)155 ?
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
-
 Geobacillus stearothermophilus S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
-
 Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
-
 Streptomyces coelicolor S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
-
 Mycolicibacterium smegmatis S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes Thermus thermophilus S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes Brachyspira hyodysenteriae S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
-
 Mycobacterium tuberculosis H37Rv S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
-
 Mycolicibacterium smegmatis mc(2)155 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes Thermus thermophilus HB8 / ATCC 27634 / DSM 579 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
-
 Brachyspira hyodysenteriae S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 23S rRNA the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes Brachyspira hyodysenteriae S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 50S rRNA
-
 Mycolicibacterium smegmatis S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 50S rRNA
-
 Brachyspira hyodysenteriae S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
-
 ?
2.1.1.226 S-adenosyl-L-methionine + cytidine1920 in 50S rRNA
-
 Mycolicibacterium smegmatis mc(2)155 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
-
 ?
2.1.1.227 additional information the TlyAII modifies C1409 in Escherichia coli 30S subunits, and activity at this site on 16S rRNA and 70S ribosomes is negligible Mycolicibacterium smegmatis ?
-
 ?
2.1.1.227 additional information the TlyAII modifies C1409 in Escherichia coli 30S subunits, and activity at this site on 16S rRNA and 70S ribosomes is negligible Mycolicibacterium smegmatis mc(2)155 ?
-
 ?
2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 16S rRNA
-
 Geobacillus stearothermophilus S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
 ?
2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 16S rRNA
-
 Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
 ?
2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 16S rRNA
-
 Streptomyces coelicolor S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
 ?
2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 16S rRNA
-
 Mycobacterium tuberculosis H37Rv S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
 ?
2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 30S rRNA
-
 Mycolicibacterium smegmatis S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 30S rRNA
-
 ?
2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 30S rRNA
-
 Mycolicibacterium smegmatis mc(2)155 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 30S rRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.226 TlyA
-
 Thermus thermophilus
2.1.1.226 TlyA
-
 Geobacillus stearothermophilus
2.1.1.226 TlyA
-
 Mycobacterium tuberculosis
2.1.1.226 TlyA
-
 Streptomyces coelicolor
2.1.1.226 TlyA
-
 Mycolicibacterium smegmatis
2.1.1.226 TlyA
-
 Brachyspira hyodysenteriae
2.1.1.226 TlyAI
-
 Thermus thermophilus
2.1.1.226 TlyAII
-
 Geobacillus stearothermophilus
2.1.1.226 TlyAII
-
 Mycobacterium tuberculosis
2.1.1.226 TlyAII
-
 Streptomyces coelicolor
2.1.1.226 TlyAII
-
 Mycolicibacterium smegmatis
2.1.1.226 TlyAII
-
 Brachyspira hyodysenteriae
2.1.1.227 TlyA
-
 Geobacillus stearothermophilus
2.1.1.227 TlyA
-
 Mycobacterium tuberculosis
2.1.1.227 TlyA
-
 Streptomyces coelicolor
2.1.1.227 TlyA
-
 Mycolicibacterium smegmatis
2.1.1.227 TlyAII
-
 Geobacillus stearothermophilus
2.1.1.227 TlyAII
-
 Mycobacterium tuberculosis
2.1.1.227 TlyAII
-
 Streptomyces coelicolor
2.1.1.227 TlyAII
-
 Mycolicibacterium smegmatis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.226 37
-
 assay at with Mycobacterium smegmatis ribosomal substrates Thermus thermophilus
2.1.1.226 37
-
 assay at with Mycobacterium smegmatis ribosomal substrates Geobacillus stearothermophilus
2.1.1.226 37
-
 assay at with Mycobacterium smegmatis ribosomal substrates Mycobacterium tuberculosis
2.1.1.226 37
-
 assay at with Mycobacterium smegmatis ribosomal substrates Streptomyces coelicolor
2.1.1.226 37
-
 assay at with Mycobacterium smegmatis ribosomal substrates Mycolicibacterium smegmatis
2.1.1.226 37
-
 assay at with Mycobacterium smegmatis ribosomal substrates Brachyspira hyodysenteriae
2.1.1.226 50
-
 assay at with Thermus thermophilus ribosomal substrates Thermus thermophilus
2.1.1.226 50
-
 assay at with Thermus thermophilus ribosomal substrates Geobacillus stearothermophilus
2.1.1.226 50
-
 assay at with Thermus thermophilus ribosomal substrates Mycobacterium tuberculosis
2.1.1.226 50
-
 assay at with Thermus thermophilus ribosomal substrates Streptomyces coelicolor
2.1.1.226 50
-
 assay at with Thermus thermophilus ribosomal substrates Mycolicibacterium smegmatis
2.1.1.226 50
-
 assay at with Thermus thermophilus ribosomal substrates Brachyspira hyodysenteriae
2.1.1.227 37
-
 assay at with Mycobacterium smegmatis ribosomal substrates Geobacillus stearothermophilus
2.1.1.227 37
-
 assay at with Mycobacterium smegmatis ribosomal substrates Mycobacterium tuberculosis
2.1.1.227 37
-
 assay at with Mycobacterium smegmatis ribosomal substrates Streptomyces coelicolor
2.1.1.227 37
-
 assay at with Mycobacterium smegmatis ribosomal substrates Mycolicibacterium smegmatis
2.1.1.227 50
-
 assay at with Thermus thermophilus ribosomal substrates Geobacillus stearothermophilus
2.1.1.227 50
-
 assay at with Thermus thermophilus ribosomal substrates Mycobacterium tuberculosis
2.1.1.227 50
-
 assay at with Thermus thermophilus ribosomal substrates Streptomyces coelicolor
2.1.1.227 50
-
 assay at with Thermus thermophilus ribosomal substrates Mycolicibacterium smegmatis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.226 7.5
-
 assay at Thermus thermophilus
2.1.1.226 7.5
-
 assay at Geobacillus stearothermophilus
2.1.1.226 7.5
-
 assay at Mycobacterium tuberculosis
2.1.1.226 7.5
-
 assay at Streptomyces coelicolor
2.1.1.226 7.5
-
 assay at Mycolicibacterium smegmatis
2.1.1.226 7.5
-
 assay at Brachyspira hyodysenteriae
2.1.1.227 7.5
-
 assay at Geobacillus stearothermophilus
2.1.1.227 7.5
-
 assay at Mycobacterium tuberculosis
2.1.1.227 7.5
-
 assay at Streptomyces coelicolor
2.1.1.227 7.5
-
 assay at Mycolicibacterium smegmatis

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.226 S-adenosyl-L-methionine
-
 Thermus thermophilus
2.1.1.226 S-adenosyl-L-methionine
-
 Geobacillus stearothermophilus
2.1.1.226 S-adenosyl-L-methionine
-
 Mycobacterium tuberculosis
2.1.1.226 S-adenosyl-L-methionine
-
 Streptomyces coelicolor
2.1.1.226 S-adenosyl-L-methionine
-
 Mycolicibacterium smegmatis
2.1.1.226 S-adenosyl-L-methionine
-
 Brachyspira hyodysenteriae
2.1.1.227 S-adenosyl-L-methionine
-
 Geobacillus stearothermophilus
2.1.1.227 S-adenosyl-L-methionine
-
 Mycobacterium tuberculosis
2.1.1.227 S-adenosyl-L-methionine
-
 Streptomyces coelicolor
2.1.1.227 S-adenosyl-L-methionine
-
 Mycolicibacterium smegmatis

General Information

EC Number General Information Comment Organism
2.1.1.226 evolution TlyA orthologues occur in diverse bacteria and fall into two distinct groups. One group, termed TlyAI, has shorter N- and C-termini and methylates only C1920. The second group, TlyAII, includes the mycobacterial enzyme, and these longer orthologues methylate at both C1409 (c.f. EC 2.1.1.227), and C1920 Thermus thermophilus
2.1.1.226 evolution TlyA orthologues occur in diverse bacteria and fall into two distinct groups. One group, termed TlyAI, has shorter N- and C-termini and methylates only C1920. The second group, TlyAII, includes the mycobacterial enzyme, and these longer orthologues methylate at both C1409 (c.f. EC 2.1.1.227), and C1920 Geobacillus stearothermophilus
2.1.1.226 evolution TlyA orthologues occur in diverse bacteria and fall into two distinct groups. One group, termed TlyAI, has shorter N- and C-termini and methylates only C1920. The second group, TlyAII, includes the mycobacterial enzyme, and these longer orthologues methylate at both C1409 (c.f. EC 2.1.1.227), and C1920 Mycobacterium tuberculosis
2.1.1.226 evolution TlyA orthologues occur in diverse bacteria and fall into two distinct groups. One group, termed TlyAI, has shorter N- and C-termini and methylates only C1920. The second group, TlyAII, includes the mycobacterial enzyme, and these longer orthologues methylate at both C1409 (c.f. EC 2.1.1.227), and C1920 Streptomyces coelicolor
2.1.1.226 evolution TlyA orthologues occur in diverse bacteria and fall into two distinct groups. One group, termed TlyAI, has shorter N- and C-termini and methylates only C1920. The second group, TlyAII, includes the mycobacterial enzyme, and these longer orthologues methylate at both C1409 (c.f. EC 2.1.1.227), and C1920 Mycolicibacterium smegmatis
2.1.1.226 evolution TlyA orthologues occur in diverse bacteria and fall into two distinct groups. One group, termed TlyAI, has shorter N- and C-termini and methylates only C1920. The second group, TlyAII, includes the mycobacterial enzyme, and these longer orthologues methylate at both C1409 (c.f. EC 2.1.1.227), and C1920 Brachyspira hyodysenteriae
2.1.1.226 malfunction inactivation of TlyA and loss of its activity confer resistance to capreomycin and viomycin Thermus thermophilus
2.1.1.226 malfunction inactivation of TlyA and loss of its activity confer resistance to capreomycin and viomycin Geobacillus stearothermophilus
2.1.1.226 malfunction inactivation of TlyA and loss of its activity confer resistance to capreomycin and viomycin Mycobacterium tuberculosis
2.1.1.226 malfunction inactivation of TlyA and loss of its activity confer resistance to capreomycin and viomycin Streptomyces coelicolor
2.1.1.226 malfunction inactivation of TlyA and loss of its activity confer resistance to capreomycin and viomycin Mycolicibacterium smegmatis
2.1.1.226 malfunction inactivation of TlyA and loss of its activity confer resistance to capreomycin and viomycin Brachyspira hyodysenteriae
2.1.1.226 additional information the cyclic peptide antibiotics capreomycin and viomycin bind on the ribosomal S70 subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA Thermus thermophilus
2.1.1.226 additional information the cyclic peptide antibiotics capreomycin and viomycin bind on the ribosomal S70 subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA Geobacillus stearothermophilus
2.1.1.226 additional information the cyclic peptide antibiotics capreomycin and viomycin bind on the ribosomal S70 subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA Mycobacterium tuberculosis
2.1.1.226 additional information the cyclic peptide antibiotics capreomycin and viomycin bind on the ribosomal S70 subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA Streptomyces coelicolor
2.1.1.226 additional information the cyclic peptide antibiotics capreomycin and viomycin bind on the ribosomal S70 subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA Mycolicibacterium smegmatis
2.1.1.226 additional information the cyclic peptide antibiotics capreomycin and viomycin bind on the ribosomal S70 subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA Brachyspira hyodysenteriae
2.1.1.227 evolution TlyA orthologues occur in diverse bacteria and fall into two distinct groups. One group, termed TlyAI, has shorter N- and C-termini and methylates only C1920. The second group, TlyAII, includes the mycobacterial enzyme, and these longer orthologues methylate at both C1409 and C1920 (c.f. EC 2.1.1.226) Geobacillus stearothermophilus
2.1.1.227 evolution TlyA orthologues occur in diverse bacteria and fall into two distinct groups. One group, termed TlyAI, has shorter N- and C-termini and methylates only C1920. The second group, TlyAII, includes the mycobacterial enzyme, and these longer orthologues methylate at both C1409 and C1920 (c.f. EC 2.1.1.226) Mycobacterium tuberculosis
2.1.1.227 evolution TlyA orthologues occur in diverse bacteria and fall into two distinct groups. One group, termed TlyAI, has shorter N- and C-termini and methylates only C1920. The second group, TlyAII, includes the mycobacterial enzyme, and these longer orthologues methylate at both C1409 and C1920 (c.f. EC 2.1.1.226) Streptomyces coelicolor
2.1.1.227 evolution TlyA orthologues occur in diverse bacteria and fall into two distinct groups. One group, termed TlyAI, has shorter N- and C-termini and methylates only C1920. The second group, TlyAII, includes the mycobacterial enzyme, and these longer orthologues methylate at both C1409 and C1920 (c.f. EC 2.1.1.226) Mycolicibacterium smegmatis
2.1.1.227 malfunction inactivation of TlyA and loss of its activity confer resistance to capreomycin and viomycin Geobacillus stearothermophilus
2.1.1.227 malfunction inactivation of TlyA and loss of its activity confer resistance to capreomycin and viomycin Mycobacterium tuberculosis
2.1.1.227 malfunction inactivation of TlyA and loss of its activity confer resistance to capreomycin and viomycin Streptomyces coelicolor
2.1.1.227 malfunction inactivation of TlyA and loss of its activity confer resistance to capreomycin and viomycin Mycolicibacterium smegmatis
2.1.1.227 additional information the cyclic peptide antibiotics capreomycin and viomycin bind on the ribosomal S70 subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA Geobacillus stearothermophilus
2.1.1.227 additional information the cyclic peptide antibiotics capreomycin and viomycin bind on the ribosomal S70 subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA Mycobacterium tuberculosis
2.1.1.227 additional information the cyclic peptide antibiotics capreomycin and viomycin bind on the ribosomal S70 subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA Streptomyces coelicolor
2.1.1.227 additional information the cyclic peptide antibiotics capreomycin and viomycin bind on the ribosomal S70 subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA Mycolicibacterium smegmatis