Literature summary extracted from

Kang, D.I.; Lee, J.Y.; Kim, W.; Jeong, K.W.; Shin, S.; Yang, J.; Park, E.; Chae, Y.K.; Kim, Y.
Discovery of novel human phenylethanolamine N-methyltransferase (hPNMT) inhibitors using 3D pharmacophore-based in silico, biophysical screening and enzymatic activity assays (2010), Mol. Cells, 29, 595-602.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.1.1.28	expressed in Escherichia coli as a His-tagged fusion protein	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.28	1,4-diaminonaphthalene-2,6-disulfonic acid	-	Homo sapiens
2.1.1.28	4-(benzo[d][1,3]dioxol-5-ylamino)-4-oxobutanoic acid	-	Homo sapiens
2.1.1.28	4-oxo-1,4-dihydroquinoline-3,7-dicarboxylic acid	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.28	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.1.1.28	using Ni-NTA chromatography	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.28	S-adenosyl-L-methionine + noradrenaline	-	Homo sapiens	S-adenosyl-L-homocysteine + epinephrine	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.28	hPNMT	-	Homo sapiens

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
2.1.1.28	37	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)