Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chen, Z.; Wang, S.P.; Krsmanovic, M.L.; Castro-Perez, J.; Gagen, K.; Mendoza, V.; Rosa, R.; Shah, V.; He, T.; Stout, S.J.; Geoghagen, N.S.; Lee, S.H.; McLaren, D.G.; Wang, L.; Roddy, T.P.; Plump, A.S.; Hubbard, B.K.; Sinz, C.J.; Johns, D.G.
    Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters (2012), Metab. Clin. Exp., 61, 470-481.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 3-{[5-(ethylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}pyrazine-2-carbonitrile compound activates plasma LCAT from multiple species in vitro Mus musculus
2.3.1.43 3-{[5-(ethylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}pyrazine-2-carbonitrile compound activates plasma LCAT from multiple species in vitro Homo sapiens
2.3.1.43 3-{[5-(ethylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}pyrazine-2-carbonitrile compound activates plasma LCAT from multiple species in vitro Macaca mulatta
2.3.1.43 3-{[5-(ethylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}pyrazine-2-carbonitrile compound activates plasma LCAT from multiple species in vitro Cricetidae

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Cricetidae
-
-
-
2.3.1.43 Homo sapiens
-
-
-
2.3.1.43 Macaca mulatta
-
-
-
2.3.1.43 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 blood plasma
-
 Mus musculus
-
2.3.1.43 blood plasma
-
 Homo sapiens
-
2.3.1.43 blood plasma
-
 Macaca mulatta
-
2.3.1.43 blood plasma
-
 Cricetidae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol proteoliposome substrates Mus musculus 1-acylglycerophosphocholine + cholesteryl ester
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol proteoliposome substrates Homo sapiens 1-acylglycerophosphocholine + cholesteryl ester
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol proteoliposome substrates Macaca mulatta 1-acylglycerophosphocholine + cholesteryl ester
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol proteoliposome substrates Cricetidae 1-acylglycerophosphocholine + cholesteryl ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Mus musculus
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 LCAT
-
 Macaca mulatta
2.3.1.43 LCAT
-
 Cricetidae
2.3.1.43 lecithin/cholesterol acyltransferase
-
 Mus musculus
2.3.1.43 lecithin/cholesterol acyltransferase
-
 Homo sapiens
2.3.1.43 lecithin/cholesterol acyltransferase
-
 Macaca mulatta
2.3.1.43 lecithin/cholesterol acyltransferase
-
 Cricetidae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.43 37
-
 assay at Mus musculus
2.3.1.43 37
-
 assay at Homo sapiens
2.3.1.43 37
-
 assay at Macaca mulatta
2.3.1.43 37
-
 assay at Cricetidae