Literature summary extracted from

Alonso, H.; Cummins, P.; Gready, J.
Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase (MeTr): Protonation state of the ligand and active-site residues (2009), J. Phys. Chem. B, 113, 14787-14796.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.258	Moorella thermoacetica	Q46389	formerly Clostridium thermoaceticum	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.258	methylcobalamin + tetrahydrofolate	-	Moorella thermoacetica	?	-	?
2.1.1.258	[Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate	the enzyme binds the protonated form of 5-methyltetrahydrofolate 10fold stronger than the unprotonated form	Moorella thermoacetica	[methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.258	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase MeTr	-	Moorella thermoacetica

pH Range

EC Number	pH Minimum	pH Maximum	Comment	Organism
2.1.1.258	5.2	6.8	the forward and reverse reaction rates decrease as the pH is lowered	Moorella thermoacetica

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Release 2023.1 (January 2023)