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Literature summary extracted from

  • Kharel, M.; Subba, B.; Lee, H.; Liou, K.; Woo, J.; Kim, D.; Moon, Y.; Sohng, J.
    Identification of 2-deoxy-scyllo-inosose synthase in aminoglycoside producer Streptomyces (2003), J. Microbiol. Biotechnol., 13, 828-831.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.124 gene btrC, DNA and amino acid sequence determination and analysis, sequence comparisons, overexpression in Escherichia coli strain BL21(DE3) Streptomyces kanamyceticus
4.2.3.124 gene btrC, DNA and amino acid sequence determination and analysis, sequence comparisons, overexpression in Escherichia coli strain BL21(DE3) Streptoalloteichus tenebrarius
4.2.3.124 gene btrC, DNA and amino acid sequence determination and analysis, sequence comparisons, overexpression in Escherichia coli strain BL21(DE3) Streptomyces ribosidificus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.3.124 Co2+ required Streptomyces kanamyceticus
4.2.3.124 Co2+ required Streptoalloteichus tenebrarius
4.2.3.124 Co2+ required Streptomyces ribosidificus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.124 D-glucose 6-phosphate Streptomyces kanamyceticus
-
 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate Streptoalloteichus tenebrarius
-
 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate Streptomyces ribosidificus
-
 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate Streptoalloteichus tenebrarius IFO 13396
-
 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate Streptomyces kanamyceticus IFO13414
-
 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate Streptomyces ribosidificus IFO13796
-
 2-deoxy-L-scyllo-inosose + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.124 no activity in Streptomyces lividans
-
-
-
4.2.3.124 no activity in Streptomyces lividans TK24
-
-
-
4.2.3.124 Streptoalloteichus tenebrarius
-
 gene btrC
-
4.2.3.124 Streptoalloteichus tenebrarius IFO 13396
-
 gene btrC
-
4.2.3.124 Streptomyces kanamyceticus
-
 gene btrC
-
4.2.3.124 Streptomyces kanamyceticus IFO13414
-
 gene btrC
-
4.2.3.124 Streptomyces ribosidificus
-
 gene btrC
-
4.2.3.124 Streptomyces ribosidificus IFO13796
-
 gene btrC
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.124 D-glucose 6-phosphate
-
 Streptomyces kanamyceticus 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate
-
 Streptoalloteichus tenebrarius 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate
-
 Streptomyces ribosidificus 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate
-
 Streptoalloteichus tenebrarius IFO 13396 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate
-
 Streptomyces kanamyceticus IFO13414 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate
-
 Streptomyces ribosidificus IFO13796 2-deoxy-L-scyllo-inosose + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.124 DOI synthase
-
 Streptomyces kanamyceticus
4.2.3.124 DOI synthase
-
 Streptoalloteichus tenebrarius
4.2.3.124 DOI synthase
-
 Streptomyces ribosidificus

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.3.124 NAD+ required Streptomyces kanamyceticus
4.2.3.124 NAD+ required Streptoalloteichus tenebrarius
4.2.3.124 NAD+ required Streptomyces ribosidificus

General Information

EC Number General Information Comment Organism
4.2.3.124 metabolism DOI synthase is a key enzyme in the biosynthesis of 2-deoxy-scyllo-inosose, DOS Streptomyces kanamyceticus
4.2.3.124 metabolism DOI synthase is a key enzyme in the biosynthesis of 2-deoxy-scyllo-inosose, DOS Streptoalloteichus tenebrarius
4.2.3.124 metabolism DOI synthase is a key enzyme in the biosynthesis of 2-deoxy-scyllo-inosose, DOS Streptomyces ribosidificus