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Literature summary extracted from

  • Veiga-da-Cunha, M.; Hadi, F.; Balligand, T.; Stroobant, V.; Van Schaftingen, E.
    Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine (2012), J. Biol. Chem., 287, 7246-7255.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.81 expression in Escherichia coli Homo sapiens
4.2.3.134 expressed in Escherichia coli as a His-tagged fusion protein Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.3.134 additional information enzyme is inhibited by excess substrate Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.81 0.0035
-
GTP pH 7.1, 30°C Homo sapiens
2.7.1.81 0.0076
-
5-hydroxy-L-lysine cosubstrate GTP, pH 7.1, 30°C Homo sapiens
2.7.1.81 0.28
-
5-hydroxy-L-lysine cosubstrate ATP, pH 7.1, 30°C Homo sapiens
2.7.1.81 0.81
-
ATP pH 7.1, 30°C Homo sapiens
4.2.3.134 0.0169
-
(5R)-5-phosphohydroxy-L-lysine pH 7.4, 30°C, Vmax: 256 nmol/min/mg Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.3.134 cytosol
-
Mus musculus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.3.134 51000
-
SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.81 Homo sapiens A2RU49
-
-
4.2.3.134 Mus musculus Q8R1K1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.81 kidney
-
Homo sapiens
-
4.2.3.134 kidney cDNA Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.81 ATP + 5-hydroxy-L-lysine catalytic efficiency is 22fold higher with GTP than with ATP Homo sapiens ADP + O-phosphohydroxy-L-lysine
-
?
2.7.1.81 GTP + 5-hydroxy-D-lysine best substrate is the physiological form 5-hydroxy-L-lysine but human enzyme can also phosphorylate at a lower rate at least one other isomer Homo sapiens GDP + O-phosphohydroxy-D-lysine
-
?
2.7.1.81 GTP + 5-hydroxy-L-lysine best substrate is the physiological form 5-hydroxy-L-lysine but human enzyme can also phosphorylate at a lower rate at least one other isomer Homo sapiens GDP + O-phosphohydroxy-L-lysine
-
?
2.7.1.81 additional information no substrates for phosphorylation: ethanolamine, hydroxyproline, homoserine, serine, or choline Homo sapiens ?
-
?
4.2.3.134 (5R)-5-phosphohydroxy-L-lysine + H2O
-
Mus musculus (S)-2-amino-6-oxohexanoate + NH3 + phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.81 AGPHD1
-
Homo sapiens
4.2.3.134 AGXT2L2
-
Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.3.134 30
-
assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.3.134 7.4
-
assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.3.134 pyridoxal 5'-phosphate
-
Mus musculus

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.7.1.81 5
-
ATP pH 7.1, 30°C Homo sapiens
2.7.1.81 12
-
5-hydroxy-L-lysine cosubstrate ATP, pH 7.1, 30°C Homo sapiens
2.7.1.81 45
-
5-hydroxy-L-lysine cosubstrate GTP, pH 7.1, 30°C Homo sapiens
2.7.1.81 110
-
GTP pH 7.1, 30°C Homo sapiens