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Literature summary extracted from

  • Amengual, J.; Golczak, M.; Palczewski, K.; von Lintig, J.
    Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein (2012), J. Biol. Chem., 287, 24216-24227.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.135 fenretinide used clinically to presumably lower blood retinol-binding protein levels and thus decrease circulating retinol, targets the functional coupling of STRA6 and LRAT to increase cellular vitamin A uptake in peripheral tissues Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein] Mus musculus
-
 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
-
 ?
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein] Mus musculus C57/BL6J / 129 Sv
-
 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.135 Mus musculus
-
 gene Lrat
-
2.3.1.135 Mus musculus C57/BL6J / 129 Sv
-
 gene Lrat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.135 eye
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein]
-
 Mus musculus 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
-
 ?
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein] refolded holo-hRBP from human serum Mus musculus 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
-
 ?
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein]
-
 Mus musculus C57/BL6J / 129 Sv 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
-
 ?
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein] refolded holo-hRBP from human serum Mus musculus C57/BL6J / 129 Sv 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.135 lecithin:retinol acyltransferase
-
 Mus musculus
2.3.1.135 LRAT
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.135 malfunction vitamin A uptake from recombinant holo-retinol-binding protein exhibited by wild-type mice is impaired in Lrat-deficient mice. Lrat-/- mice show elevated cellular vitamin A-binding protein 1, CRBP1, protein in the liver, lung, and adipose tissue as compared with wild type control animals Mus musculus
2.3.1.135 physiological function lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein, which depends on functional coupling of STRA6 with intracellular lecithin:retinol acyltransferase. Vitamin A uptake is regulated by all-trans-retinoic acid in nonocular tissues of mice. When in excess, vitamin A is rapidly taken up and converted to its inert ester form in peripheral tissues, such as lung, whereas in vitamin A deficiency, ocular retinoid uptake is favored Mus musculus