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Literature summary extracted from

  • Ribardo, D.A.; Hendrixson, D.R.
    Analysis of the LIV system of Campylobacter jejuni reveals alternative roles for LivJ and LivK in commensalism beyond branched-chain amino acid transport (2011), J. Bacteriol., 193, 6233-6243.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
7.4.2.2 additional information generation of diverse liv gene deletion mutant strains, DELTAlivJ mutant shows a 10fold reduction in leucine transport, DELTAlivK mutant shows 43fold reduction compared to the wild-type activity, deletion of both livJ and livK reduces the transport of leucine to over 200fold lower than that for wild-type cells. Also deletion of other liv gene either individually, e.g., DELTAlivH, DELTAlivM, DELTAlivG, or DELTAlivF, or as paired double mutants essentially abolishes transport of leucine. Deletion of both livJ and livK as well as both permeases or ATPases results in abolishment of transport of isoleucine and valine Campylobacter jejuni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.4.2.2 ATP + H2O + L-leucine/out Campylobacter jejuni specificity of leucine-mediated transport by the LIV system of Campylobacter jejuni, overview. The LIV system is largely limited to leucine, isoleucine, and valine ADP + phosphate + L-leucine/in
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 ?
7.4.2.2 ATP + H2O + L-leucine/out Campylobacter jejuni 81-176 specificity of leucine-mediated transport by the LIV system of Campylobacter jejuni, overview. The LIV system is largely limited to leucine, isoleucine, and valine ADP + phosphate + L-leucine/in
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 ?

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.2 Campylobacter jejuni
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 clinical isolate, live genes encoded in the liv operon
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7.4.2.2 Campylobacter jejuni 81-176
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 clinical isolate, live genes encoded in the liv operon
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.4.2.2 ATP + H2O + L-isoleucine/out 19fold less transport compared to leucine Campylobacter jejuni ADP + phosphate + L-isoleucine/in
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 ?
7.4.2.2 ATP + H2O + L-isoleucine/out 19fold less transport compared to leucine Campylobacter jejuni 81-176 ADP + phosphate + L-isoleucine/in
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 ?
7.4.2.2 ATP + H2O + L-leucine/out
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 Campylobacter jejuni ADP + phosphate + L-leucine/in
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 ?
7.4.2.2 ATP + H2O + L-leucine/out specificity of leucine-mediated transport by the LIV system of Campylobacter jejuni, overview. The LIV system is largely limited to leucine, isoleucine, and valine Campylobacter jejuni ADP + phosphate + L-leucine/in
-
 ?
7.4.2.2 ATP + H2O + L-leucine/out
-
 Campylobacter jejuni 81-176 ADP + phosphate + L-leucine/in
-
 ?
7.4.2.2 ATP + H2O + L-leucine/out specificity of leucine-mediated transport by the LIV system of Campylobacter jejuni, overview. The LIV system is largely limited to leucine, isoleucine, and valine Campylobacter jejuni 81-176 ADP + phosphate + L-leucine/in
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 ?
7.4.2.2 ATP + H2O + L-valine/out 45fold less transport compared to leucine Campylobacter jejuni ADP + phosphate + L-valine/in
-
 ?
7.4.2.2 ATP + H2O + nonpolar amino acid/out
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 Campylobacter jejuni ADP + phosphate + nonpolar amino acid/in
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 ?
7.4.2.2 ATP + H2O + nonpolar amino acid/out
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 Campylobacter jejuni 81-176 ADP + phosphate + nonpolar amino acid/in
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 ?
7.4.2.2 additional information LIV proteins are involved in transport of other branched-chain amino acids but at more modest levels than observed for leucine, comparison of activities of wild-type and mutant strains, overview Campylobacter jejuni ?
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 ?
7.4.2.2 additional information LIV proteins are involved in transport of other branched-chain amino acids but at more modest levels than observed for leucine, comparison of activities of wild-type and mutant strains, overview Campylobacter jejuni 81-176 ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
7.4.2.2 branched-chain amino acid transporter
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 Campylobacter jejuni

Expression

EC Number Organism Comment Expression
7.4.2.2 Campylobacter jejuni livJ expression is not induced by leucine additional information

General Information

EC Number General Information Comment Organism
7.4.2.2 physiological function LivJ and LivK are required for optimal commensal colonization of the chick ceca Campylobacter jejuni