EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.98.3 | C387G | mutation confers resistance to 1-methyl-2,4,7-trinitroxanthone and to 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide | Mycobacterium tuberculosis |
1.1.98.3 | C387S | mutation confers resistance to 1-methyl-2,4,7-trinitroxanthone and to 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.98.3 | 1-methyl-2,4,7-trinitroxanthone | mutations C387S and C387G confer resistance to 1-methyl-2,4,7-trinitroxanthone | Mycobacterium tuberculosis | |
1.1.98.3 | 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one | tuberculosis drug candidate with high activity against Mycobacterium tuberculosis in vitro and in vivo. Compound is activated in the bacterium by reduction of an essential nitro group to a nitroso derivative, which then specifically reacts with a cysteine residue in the active site of DprE1 | Mycobacterium tuberculosis | |
1.1.98.3 | 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide | high activity against Mycobacterium smegmatis and Mycobacterium tuberculosis H37Rv but no significant activity against benzothiazinone-resistant strains with the mutations Cys387Ser or Cys387Gly in DprE1 | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.98.3 | Mycobacterium tuberculosis | P9WJF1 | - |
- |
1.1.98.3 | Mycobacterium tuberculosis H37Rv | P9WJF1 | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.98.3 | DprE1 | - |
Mycobacterium tuberculosis |