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Literature summary extracted from

  • Cheng, J.; Coyle, C.; Panaccione, D.; O’Connor, S.
    Controlling a structural branch point in ergot alkaloid biosynthesis (2010), J. Am. Chem. Soc., 132, 12835-12837.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.5.1.44 F176Y the mutant produces agroclavine from chanoclavine-I aldehyde Aspergillus fumigatus
1.5.1.44 Y178F the activity of the mutant is not qualitatively different from wild type enzyme Aspergillus fumigatus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.44 Aspergillus fumigatus
-
-
-
1.5.1.46 Aspergillus fumigatus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.44 festuclavine + NAD+
-
 Aspergillus fumigatus 6,8-dimethyl-6,7-didehydroergoline + NADH + H+
-
 r
1.5.1.46 (8beta,10beta)-6-amino-8-methyl-6,7-didehydroergolin-6-ium + NADPH + H+
-
 Aspergillus fumigatus festuclavine + NADP+
-
 ?
1.5.1.46 6,8-dimethyl-6,7,8,9-tetradehydroergoline + NADPH + H+
-
 Aspergillus fumigatus agroclavine + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.44 EasA
-
 Aspergillus fumigatus
1.5.1.44 festuclavine synthase
-
 Aspergillus fumigatus
1.5.1.46 EasG
-
 Aspergillus fumigatus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.46 NADPH dependent on Aspergillus fumigatus