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Literature summary extracted from

  • Watterlot, L.; Meyrand, M.; Gaide, N.; Kharrat, P.; Blugeon, S.; Gratadoux, J.J.; Flores, M.J.; Langella, P.; Chapot-Chartier, M.P.; Bermudez-Humaran, L.G.
    Variations of N-acetylation level of peptidoglycan do not influence persistence of Lactococcus lactis in the gastrointestinal tract (2010), Int. J. Food Microbiol., 144, 29-34.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.104 medicine construction of a mutant pgdA strain and a pgdA-overexpressing strain and comparison of the pharmacokinetics properties of these recombinant strains with that of a wild-type strain, all producing the same model antigen, the human papillomavirus type-16 E7 protein, in the gastrointestinal tract of mice. There is no correlation between survival, at the ileum level, of bacteria intragastrically administered in mice and bacteria sensitivity or resistance to lysozyme. Neither lysozyme-sensitive nor lysozyme-resistant phenotype in Lactococcus lactis enhances significantly the potential of this bacterium as mucosal delivery live vector Lactococcus lactis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.33 N-acetyl-D-glucosamine + H2O Lactococcus lactis
-
 D-glucosamine + acetate
-
 ?
3.5.1.33 N-acetyl-D-glucosamine + H2O Lactococcus lactis JIM7049
-
 D-glucosamine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.33 Lactococcus lactis
-
-
-
3.5.1.33 Lactococcus lactis JIM7049
-
-
-
3.5.1.104 Lactococcus lactis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.33 N-acetyl-D-glucosamine + H2O
-
 Lactococcus lactis D-glucosamine + acetate
-
 ?
3.5.1.33 N-acetyl-D-glucosamine + H2O
-
 Lactococcus lactis JIM7049 D-glucosamine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.33 pgdA
-
 Lactococcus lactis

General Information

EC Number General Information Comment Organism
3.5.1.33 malfunction inactivation of the N-acetylglucosamine deacetylase gene leads to fully acetylated peptidoglycan, resulting in a lysozyme-sensitive phenotype Lactococcus lactis
3.5.1.33 physiological function N-acetylglucosamine deacetylase gene overexpression leads to an increased degree of peptidoglycan deacetylation, resulting in a lysozyme-resistant phenotype. N-Acetylglucosamine deacetylase does not confer any advantage in the persistence of Lactococcus lactis in the gastrointestinal tract and its ability to enhance host immune responses induced by delivered antigen in situ Lactococcus lactis
3.5.1.104 physiological function construction of a mutant pgdA strain and a pgdA-overexpressing strain and comparison of the pharmacokinetics properties of these recombinant strains with that of a wild-type strain, all producing the same model antigen, the human papillomavirus type-16 E7 protein, in the gastrointestinal tract of mice. There is no correlation between survival, at the ileum level, of bacteria intragastrically administered in mice and bacteria sensitivity or resistance to lysozyme. Neither lysozyme-sensitive nor lysozyme-resistant phenotype in Lactococcus lactis enhances significantly the potential of this bacterium as mucosal delivery live vector Lactococcus lactis