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Literature summary extracted from

  • Cenas, N.; Marcinkeviciene, J.; Kulys, J.; Usanov, S.
    A negative cooperativity between NADPH and adrenodoxin on binding to NADPH:adrenodoxin reductase (1990), FEBS Lett., 259, 338-340.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.18.1.6 mitochondrion
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 Bos taurus 5739
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Organism

EC Number Organism UniProt Comment Textmining
1.18.1.6 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.18.1.6 adrenal cortex
-
 Bos taurus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.18.1.6 additional information adrenodoxin stimulates the oxidation of NADPH by 1,4-benzoquinone, catalyzed by NADPH:adrenodoxin reductase. It prevents the enzyme inhibition by NADPH and forms an additional pathway of benzoquinone reduction presumably via reduced adrenodoxin. Adrenodoxin decreases the affinity of the enzyme for NADPH by a limiting factor of 3 and NADP+ decreases the enzyme affinity for adrenodoxin Bos taurus ?
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 ?
1.18.1.6 reduced adrenodoxin + NADP
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 Bos taurus oxidized adrenodoxin + NADPH + H+
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.18.1.6 AdR
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 Bos taurus
1.18.1.6 adrenodoxin reductase
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 Bos taurus
1.18.1.6 NADPH:adrenodoxin reductase
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 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.18.1.6 FAD
-
 Bos taurus

General Information

EC Number General Information Comment Organism
1.18.1.6 metabolism the enzyme functions in the mitochondrial electron transport chain for cytochrome P450-dependent steroid hydroxylation by donating the electrons to adrenodoxin which further transfers them to cytochromes P450scc or P4511beta Bos taurus