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Literature summary extracted from
- Structural insights from random mutagenesis of Campylobacter jejuni oligosaccharyltransferase PglB (2012), BMC Biotechnol., 12, 67.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 2.4.99.19 | medicine | application for protein glycosylation in recombinant bacteria in the production of potent conjugate vaccines where polysaccharide antigens of pathogenic bacteria are covalently bound to immunogenic carrier proteins | Campylobacter jejuni |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.4.99.19 | gene pglB, functional expression in Escherichia coli | Campylobacter jejuni |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.99.19 | tritrans,heptacis-undecaprenyl diphosphooligosaccharide + [protein]-L-asparagine | Campylobacter jejuni | - |
tritrans,heptacis-undecaprenyl diphosphate + [protein]-L-asparagine-oligosaccharide | a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to protein L-asparagine | ? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.4.99.19 | Campylobacter jejuni | - |
gene pglB | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.99.19 | tritrans,heptacis-undecaprenyl diphosphooligosaccharide + [protein]-L-asparagine | - |
Campylobacter jejuni | tritrans,heptacis-undecaprenyl diphosphate + [protein]-L-asparagine-oligosaccharide | a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to protein L-asparagine | ? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.4.99.19 | N-oligosaccharyltransferase | - |
Campylobacter jejuni |
| 2.4.99.19 | oligosaccharyltransferase | - |
Campylobacter jejuni |
| 2.4.99.19 | PglB | - |
Campylobacter jejuni |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.4.99.19 | additional information | structure-function relationships for the periplasmic domain of the N-oligosaccharyltransferase PglB, overview | Campylobacter jejuni |
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Release 2023.1 (January 2023)
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