Literature summary extracted from

Song, X.; Geng, Z.; Li, X.; Hu, X.; Bian, N.; Zhang, X.; Wang, Z.
New insights into the mechanism of arsenite methylation with the recombinant human arsenic (+3) methyltransferase (hAS3MT) (2010), Biochimie, 92, 1397-1406.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.1.1.137	glutathione	GSH should combine with the enzyme after the methylation to reduce the disulfide bond formed during the catalytic cycle to resume the active form of the enzyme	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.137	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.137	S-adenosyl-L-methionine + arsenite	maximal conversion of arsenite to monomethylarsonate occurs at about 0.1 mM arsenite. Higher substrate concentrations inhibit monomethylarsonate yields. The production of dimethylarsinic acid increases as arsenite concentration increases from 0.0005 to 0.0083 mM, and then quickly decreases to zero	Homo sapiens	S-adenosyl-L-homocysteine + monomethylarsonate + dimethylarsinic acid	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.137	arsenic (+3) methyltransferase	-	Homo sapiens
2.1.1.137	AS3MT	-	Homo sapiens

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.1.1.137	8.5	-	-	Homo sapiens

pH Range

EC Number	pH Minimum	pH Maximum	Comment	Organism
2.1.1.137	7	10	-	Homo sapiens

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Release 2023.1 (January 2023)