BRENDA - Enzyme Database

Phospholipid flippases: Building asymmetric membranes and transport vesicles

Sebastian, T.T.; Baldridge, R.D.; Xu, P.; Graham, T.R.; Biochim. Biophys. Acta 1821, 1068-1077 (2012)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
7.6.2.1
ALIS protein
-
Arabidopsis thaliana
7.6.2.1
CDC50A
-
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.1
endosome
-
Arabidopsis thaliana
5768
-
7.6.2.1
endosome
-
Caenorhabditis elegans
5768
-
7.6.2.1
endosome
-
Saccharomyces cerevisiae
5768
-
7.6.2.1
endosome
-
Homo sapiens
5768
-
7.6.2.1
Golgi apparatus
-
Arabidopsis thaliana
5794
-
7.6.2.1
Golgi apparatus
-
Caenorhabditis elegans
5794
-
7.6.2.1
Golgi apparatus
-
Saccharomyces cerevisiae
5794
-
7.6.2.1
Golgi apparatus
-
Homo sapiens
5794
-
7.6.2.1
plasma membrane
-
Caenorhabditis elegans
5886
-
7.6.2.1
plasma membrane
-
Homo sapiens
5886
-
7.6.2.1
plasma membrane
-
Arabidopsis thaliana
5886
-
7.6.2.1
plasma membrane
-
Saccharomyces cerevisiae
5886
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
7.6.2.1
Arabidopsis thaliana
-
-
-
7.6.2.1
Caenorhabditis elegans
C7U324
-
-
7.6.2.1
Caenorhabditis elegans
G5EBH1
-
-
7.6.2.1
Caenorhabditis elegans
O18182
-
-
7.6.2.1
Caenorhabditis elegans
P91203
-
-
7.6.2.1
Caenorhabditis elegans
Q7YXV5
-
-
7.6.2.1
Homo sapiens
-
-
-
7.6.2.1
Saccharomyces cerevisiae
P32660
-
-
7.6.2.1
Saccharomyces cerevisiae
P39524
-
-
7.6.2.1
Saccharomyces cerevisiae
Q12674
-
-
7.6.2.1
Saccharomyces cerevisiae
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
7.6.2.1
blood platelet
-
Homo sapiens
-
7.6.2.1
erythrocyte
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.6.2.1
ATP + H2O + phosphatidylethanolamine/in
-
718993
Homo sapiens
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylethanolamine/in
-
718993
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylethanolamine/in
-
718993
Arabidopsis thaliana
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylethanolamine/in
-
718993
Caenorhabditis elegans
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/in
-
718993
Homo sapiens
ADP + phosphate + phosphatidylserine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/in
-
718993
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylserine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/in
-
718993
Arabidopsis thaliana
ADP + phosphate + phosphatidylserine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/in
-
718993
Caenorhabditis elegans
ADP + phosphate + phosphatidylserine/out
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
7.6.2.1
heterodimer
-
Arabidopsis thaliana
7.6.2.1
heterodimer
-
Caenorhabditis elegans
7.6.2.1
heterodimer
-
Homo sapiens
7.6.2.1
heterodimer
-
Saccharomyces cerevisiae
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
7.6.2.1
ALIS protein
-
Arabidopsis thaliana
7.6.2.1
CDC50A
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.1
endosome
-
Arabidopsis thaliana
5768
-
7.6.2.1
endosome
-
Caenorhabditis elegans
5768
-
7.6.2.1
endosome
-
Homo sapiens
5768
-
7.6.2.1
endosome
-
Saccharomyces cerevisiae
5768
-
7.6.2.1
Golgi apparatus
-
Arabidopsis thaliana
5794
-
7.6.2.1
Golgi apparatus
-
Caenorhabditis elegans
5794
-
7.6.2.1
Golgi apparatus
-
Homo sapiens
5794
-
7.6.2.1
Golgi apparatus
-
Saccharomyces cerevisiae
5794
-
7.6.2.1
plasma membrane
-
Caenorhabditis elegans
5886
-
7.6.2.1
plasma membrane
-
Saccharomyces cerevisiae
5886
-
7.6.2.1
plasma membrane
-
Homo sapiens
5886
-
7.6.2.1
plasma membrane
-
Arabidopsis thaliana
5886
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
7.6.2.1
blood platelet
-
Homo sapiens
-
7.6.2.1
erythrocyte
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.6.2.1
ATP + H2O + phosphatidylethanolamine/in
-
718993
Homo sapiens
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylethanolamine/in
-
718993
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylethanolamine/in
-
718993
Arabidopsis thaliana
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylethanolamine/in
-
718993
Caenorhabditis elegans
ADP + phosphate + phosphatidylethanolamine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/in
-
718993
Homo sapiens
ADP + phosphate + phosphatidylserine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/in
-
718993
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylserine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/in
-
718993
Arabidopsis thaliana
ADP + phosphate + phosphatidylserine/out
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/in
-
718993
Caenorhabditis elegans
ADP + phosphate + phosphatidylserine/out
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
7.6.2.1
heterodimer
-
Arabidopsis thaliana
7.6.2.1
heterodimer
-
Caenorhabditis elegans
7.6.2.1
heterodimer
-
Homo sapiens
7.6.2.1
heterodimer
-
Saccharomyces cerevisiae
General Information
EC Number
General Information
Commentary
Organism
7.6.2.1
malfunction
knockdown of ALA1 expression causes a cold-sensitive growth defect in plants
Arabidopsis thaliana
7.6.2.1
malfunction
P4-ATPase deficiencies are linked to liver disease, obesity, diabetes, hearing loss, neurological deficits, immune deficiency, and reduced fertility
Homo sapiens
7.6.2.1
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Arabidopsis thaliana
7.6.2.1
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Caenorhabditis elegans
7.6.2.1
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Homo sapiens
7.6.2.1
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes; the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Saccharomyces cerevisiae
General Information (protein specific)
EC Number
General Information
Commentary
Organism
7.6.2.1
malfunction
knockdown of ALA1 expression causes a cold-sensitive growth defect in plants
Arabidopsis thaliana
7.6.2.1
malfunction
P4-ATPase deficiencies are linked to liver disease, obesity, diabetes, hearing loss, neurological deficits, immune deficiency, and reduced fertility
Homo sapiens
7.6.2.1
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Arabidopsis thaliana
7.6.2.1
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Caenorhabditis elegans
7.6.2.1
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Homo sapiens
7.6.2.1
physiological function
the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes
Saccharomyces cerevisiae