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Literature summary extracted from
- Isolation and cloning of the K+-independent, ouabain-insensitive Na+-ATPase (2011), Biochim. Biophys. Acta, 1808, 1684-1700.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.3 | Furosemide | - |
Cavia porcellus |  |
| 7.2.2.3 | additional information | not inhibited by 1 mM ouabain | Cavia porcellus | |
| 7.2.2.3 | vanadate | - |
Cavia porcellus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.2.3 | plasma membrane | - |
Cavia porcellus | 5886 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.3 | Mg2+ | dependent on | Cavia porcellus | |
| 7.2.2.3 | additional information | not influenced by K+ | Cavia porcellus | |
| 7.2.2.3 | Na+ | stimulates activity | Cavia porcellus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.3 | 50000 | - |
1 * 90000 + 1 * 50000, SDS-PAGE | Cavia porcellus |
| 7.2.2.3 | 90000 | - |
1 * 90000 + 1 * 50000, SDS-PAGE | Cavia porcellus |
| 7.2.2.3 | 113000 | - |
calculated from amino acid sequence | Cavia porcellus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.3 | Cavia porcellus | B3SI05 | alpha subunit | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.2.2.3 | concanavalin A affinity column chromatography and Q-Sepharose column chromatography | Cavia porcellus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.2.2.3 | enterocyte | - |
Cavia porcellus | - |
| 7.2.2.3 | epithelial cell | - |
Cavia porcellus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.3 | ATP + H2O + Na+/in | - |
Cavia porcellus | ADP + phosphate + Na+/out | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.2.2.3 | heterodimer | 1 * 90000 + 1 * 50000, SDS-PAGE | Cavia porcellus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.3 | Na+-ATPase | - |
Cavia porcellus |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 7.2.2.3 | Cavia porcellus | calculated from amino acid sequence | - |
5.4 |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 7.2.2.3 | 0.0091 | - |
pH and temperature not specified in the publication | Cavia porcellus | vanadate | |
| 7.2.2.3 | 0.5 | - |
pH and temperature not specified in the publication | Cavia porcellus | Furosemide | |
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Release 2023.1 (January 2023)
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