Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Drinkwater, N.; Vu, H.; Lovell, K.M.; Criscione, K.R.; Collins, B.M.; Prisinzano, T.E.; Poulsen, S.A.; McLeish, M.J.; Grunewald, G.L.; Martin, J.L.
    Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors (2010), Biochem. J., 431, 51-61.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.28 C-terminally His-tagged hPNMT is expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.28 1-aminoisoquinoline Kd: 14 microM Homo sapiens
2.1.1.28 2-amino-1-methylbenzimidazole Kd: 4.6 microM Homo sapiens
2.1.1.28 2-amino-4(7)-hydroxy-benzimidazole Kd: 20 microM Homo sapiens
2.1.1.28 2-amino-5(6)-chloro-7(4)-hydroxy-benzimidazole Kd: 14 microM Homo sapiens
2.1.1.28 2-amino-5(6)-chloro-benzimidazole Kd: 1.8 microM Homo sapiens
2.1.1.28 2-amino-5(6)-fluoro-benzimidazole Kd: 7.2 microM Homo sapiens
2.1.1.28 2-aminobenzimidazole Kd: 6.3 microM Homo sapiens
2.1.1.28 4-bromo-1H-imidazole Kd: 170 microM Homo sapiens
2.1.1.28 4-quinolinol Kd: 690 microM Homo sapiens
2.1.1.28 5-chlorobenzimidazole Kd: 97 microM Homo sapiens
2.1.1.28 6-Aminoquinoline Kd: 380 microM Homo sapiens
2.1.1.28 6-Chloropurine Kd: 140 microM Homo sapiens
2.1.1.28 adenine Kd: 180 microM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.28 Homo sapiens
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.1.1.28 hPNMT
-
 Homo sapiens