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Literature summary extracted from

  • Matsuo, M.; Terai, K.; Kameda, N.; Matsumoto, A.; Kurokawa, Y.; Funase, Y.; Nishikawa, K.; Sugaya, N.; Hiruta, N.; Kishimoto, T.
    Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma (2012), Biochem. Biophys. Res. Commun., 420, 901-906.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.13 medicine isoform Glyat expression is suppressed in all hepatocellular carcinomas, but not in other liver diseases. Glyat repression in cancerous cells in the liver is controlled at the transcriptional level Homo sapiens
2.3.1.71 medicine isoform Glyat expression is suppressed in all hepatocellular carcinomas, but not in other liver diseases. Glyat repression in cancerous cells in the liver is controlled at the transcriptional level Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.13 mitochondrion
-
Homo sapiens 5739
-
2.3.1.71 mitochondrion
-
Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.13 Homo sapiens Q6IB77 isoform Glyat
-
2.3.1.71 Homo sapiens Q6IB77 isoform Glyat
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.13 benzoyl-CoA + glycine best substrates are benzoyl-CoA as an acyl donor and glycine as acyl acceptor Homo sapiens CoA + N-benzoylglycine
-
?
2.3.1.13 benzoyl-CoA + L-glutamine 24% of the rate with glycine and benzoyl-CoA Homo sapiens CoA + N-benzoyl-L-glutamine
-
?
2.3.1.71 benzoyl-CoA + glycine best substrates are benzoyl-CoA as an acyl donor and glycine as acyl acceptor Homo sapiens CoA + N-benzoylglycine
-
?
2.3.1.71 benzoyl-CoA + L-glutamine 24% of the rate with glycine and benzoyl-CoA Homo sapiens CoA + N-benzoyl-L-glutamine
-
?
2.3.1.71 phenylacetyl-CoA + glycine 22% of the rate with glycine and benzoyl-CoA Homo sapiens CoA + N-phenylacetylglycine
-
?
2.3.1.71 phenylacetyl-CoA + L-glutamine 20% of the rate with glycine and benzoyl-CoA Homo sapiens CoA + N-phenylacetyl-L-glutamine
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.13 GlyAT
-
Homo sapiens
2.3.1.71 GlyAT
-
Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.13 Homo sapiens isoform Glyat expression is suppressed in all hepatocellular carcinomas, but not in other liver diseases. Glyat repression in cancerous cells in the liver is controlled at the transcriptional level down
2.3.1.71 Homo sapiens isoform Glyat expression is suppressed in all hepatocellular carcinomas, but not in other liver diseases. Glyat repression in cancerous cells in the liver is controlled at the transcriptional level down