BRENDA - Enzyme Database show

Genetic variants associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase show wide variation across multiple populations

Fujihara, J.; Yasuda, T.; Kato, H.; Yuasa, I.; Panduro, A.; Kunito, T.; Takeshita, H.; Arch. Toxicol. 85, 119-125 (2011)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.1.1.137
M287T
the mutation is associated with an increased percentage of monomethylated arsenic in urine
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.137
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
718712
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.1.1.137
M287T
the mutation is associated with an increased percentage of monomethylated arsenic in urine
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
718712
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?