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Literature summary extracted from

  • Du, Y.; Gisselberg, J.E.; Johnson, J.D.; Lee, P.J.; Prigge, S.T.; Bachmann, B.O.
    Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener (2010), Appl. Environ. Microbiol., 76, 3959-3966.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.180 codon optimized gene expressed in Lactococcus lactis CL112 (fabH knockout strain) Plasmodium falciparum
2.3.1.180 expressed in Lactococcus lactis CL112 (fabH knockout strain) Lactococcus lactis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.180 cerulenin
-
 Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.180 Lactococcus lactis Q9CHG0
-
-
2.3.1.180 Lactococcus lactis IL1403 Q9CHG0
-
-
2.3.1.180 Plasmodium falciparum O77078
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.180 truncated construct encoding residue 50 - 371 Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.180 acetyl-CoA + ACP acetyl-CoA:ACP transacylase activity Plasmodium falciparum acetyl-ACP + CoA
-
 ?
2.3.1.180 malonyl-ACP + acetyl-CoA
-
 Plasmodium falciparum CO2 + CoA + acetoacetyl-ACP
-
 ?
2.3.1.180 malonyl-ACP + acetyl-CoA
-
 Lactococcus lactis CO2 + CoA + acetoacetyl-ACP
-
 ?
2.3.1.180 malonyl-ACP + acetyl-CoA
-
 Lactococcus lactis IL1403 CO2 + CoA + acetoacetyl-ACP
-
 ?
2.3.1.180 malonyl-ACP + acyl-CoA
-
 Plasmodium falciparum CO2 + CoA + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.180 beta-ketoacyl-acyl carrier protein synthase III
-
 Lactococcus lactis
2.3.1.180 beta-ketoacyl-acyl carrier protein synthase III also catalyzing acetyl-CoA:ACP transacylase reaction Plasmodium falciparum