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Literature summary extracted from

  • Jimenez-Ortigosa, C.; Aimanianda, V.; Muszkieta, L.; Mouyna, I.; Alsteens, D.; Pire, S.; Beau, R.; Krappmann, S.; Beauvais, A.; Dufrene, Y.F.; Roncero, C.; Latge, J.P.
    Chitin synthases with a myosin motor-like domain controls the resistance of Aspergillus fumigatus to echinocandins (2012), Antimicrob. Agents Chemother., 56, 6121-6131.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.16 Aspergillus fumigatus
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.16 CsmA
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 Aspergillus fumigatus
2.4.1.16 CsmB
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 Aspergillus fumigatus

General Information

EC Number General Information Comment Organism
2.4.1.16 physiological function in the conidia, chitin content in the cell wall of a mutant strain lacking activity of isoform csmA is less than half the amount found in the parental strain. The isoform csmB mutant strain and the isoform csmA/csmB double mutant strain do not show any modification of chitin content in their conidial cell walls. In contrast to the hydrophobic conidia of the parental strain, conidia of all of the chitin synthase mutants are hydrophilic due to the presence of an amorphous material covering the hydrophobic surface-rodlet layer. The deletion of chitin synthase genes also results in an increased susceptibility of resting and germinating conidia to echinocandins Aspergillus fumigatus