EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.21 | malonyl-CoA | - |
Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.21 | 0.079 | - |
palmitoyl-CoA | mitochondria isolated from newborn pig, pH 7.2, 30°C | Sus scrofa | |
2.3.1.21 | 0.142 | - |
palmitoyl-CoA | mitochondria isolated from 24-h-old, fed pig, pH 7.2, 30°C | Sus scrofa | |
2.3.1.21 | 0.293 | - |
palmitoyl-CoA | mitochondria isolated from 24-h-old, fasted pig, pH 7.2, 30°C | Sus scrofa | |
2.3.1.21 | 0.461 | - |
palmitoyl-CoA | mitochondria isolated from adult pig, pH 7.2, 30°C | Sus scrofa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.21 | mitochondrion | of newborn, 24-h old, fed or fasted, and 5-months-old pigs | Sus scrofa | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.21 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.21 | L-carnitine + palmitoyl-CoA | - |
Sus scrofa | L-palmitoylcarnitine + CoA | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.21 | CPT I | - |
Sus scrofa |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.21 | 0.00019 | - |
mitochondria isolated from newborn pig, pH 7.2, 30°C | Sus scrofa | malonyl-CoA | |
2.3.1.21 | 0.00021 | - |
mitochondria isolated from adult pig, pH 7.2, 30°C | Sus scrofa | malonyl-CoA | |
2.3.1.21 | 0.00026 | - |
mitochondria isolated from 24-h-old, fed pig, pH 7.2, 30°C | Sus scrofa | malonyl-CoA | |
2.3.1.21 | 0.00053 | - |
mitochondria isolated from 24-h-old, fasted pig, pH 7.2, 30°C | Sus scrofa | malonyl-CoA |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.21 | physiological function | measurements of enzyme activity in mitochondria isolated from newborn, 24-h-old, fed or fasted, and 5-months-old pigs. Acetate rather than ketone bodies is the predominant radiolabeled product, and its production increases twofold with increasing fatty acid oxidation during the first 24-h suckling period. The rate of acetogenesis is directly proportional to isoform CPT I activity. The high activity of CPT I in 24-h-suckling piglets is not attributable to an increase in CPT I gene expression, but rather to a large decrease in the sensitivity of CPT I to malonyl-CoA inhibition, which offsets a developmental decrease in affinity of CPT I for palmitoyl-CoA. Acetate is the primary product of hepatic mitochondrial beta-oxidation in Sus scrofa and regulation during early development is mediated primarily via kinetic modulation of isoform CPT I. | Sus scrofa |