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Literature summary extracted from

  • Zhang, J.; Angala, S.K.; Pramanik, P.K.; Li, K.; Crick, D.C.; Liav, A.; Jozwiak, A.; Swiezewska, E.; Jackson, M.; Chatterjee, D.
    Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors (2011), ACS Chem. Biol., 6, 819-828.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.47 additional information AftC is active only when reconstituted in a proteoliposome Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.47 expressed in Mycobacterium smegmatis mc2155/pJAM/Rv2673 cells Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.47 membrane
-
 Mycobacterium tuberculosis 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.47 38000
-
 x * 38000, SDS-PAGE Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.47 Mycobacterium tuberculosis
-
-
-
2.4.2.47 Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.47 metal affinity column column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.47 (2Z,6Z)-farnesylphospho-alpha-D-arabinofuranoside + octyl (alpha-D-Araf)2-(1->3,5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis ?
-
 ?
2.4.2.47 (2Z,6Z)-farnesylphospho-alpha-D-arabinofuranoside + octyl (alpha-D-Araf)2-(1->3,5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis H37Rv ?
-
 ?
2.4.2.47 (2Z,6Z)-farnesylphospho-alpha-D-arabinofuranoside + octyl alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis ?
-
 ?
2.4.2.47 (2Z,6Z)-farnesylphospho-alpha-D-arabinofuranoside + octyl alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis H37Rv ?
-
 ?
2.4.2.47 decaprenylphospho-alpha-D-arabinofuranoside + octyl alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis ?
-
 ?
2.4.2.47 decaprenylphospho-alpha-D-arabinofuranoside + octyl alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis H37Rv ?
-
 ?
2.4.2.47 ditrans,tetracis-heptaprenylphospho-alpha-D-arabinofuranoside + octyl alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis ?
-
 ?
2.4.2.47 additional information no activity with octyl alpha-D-Araf-(1->5)-alpha-D-Araf and dipalmitoyl phosphatidylcholine Mycobacterium tuberculosis ?
-
 ?
2.4.2.47 additional information the enzyme introduces alpha-(1->3) branch points in the internal arabinan domain in both arabinogalactan and lipoarabinomannan synthesis. The enzyme can only transfer D-arabinofuranose when a minimum of three arabinofuranosyl residues are present in a linear structure in order to introduce an alpha-D-Araf-(1->3) branch point Mycobacterium tuberculosis ?
-
 ?
2.4.2.47 additional information no activity with octyl alpha-D-Araf-(1->5)-alpha-D-Araf and dipalmitoyl phosphatidylcholine Mycobacterium tuberculosis H37Rv ?
-
 ?
2.4.2.47 additional information the enzyme introduces alpha-(1->3) branch points in the internal arabinan domain in both arabinogalactan and lipoarabinomannan synthesis. The enzyme can only transfer D-arabinofuranose when a minimum of three arabinofuranosyl residues are present in a linear structure in order to introduce an alpha-D-Araf-(1->3) branch point Mycobacterium tuberculosis H37Rv ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.47 ? x * 38000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.4.2.47 1,3-alpha-arabinosyltransferase
-
 Mycobacterium tuberculosis
2.4.2.47 AftC
-
 Mycobacterium tuberculosis
2.4.2.47 Rv2673
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.4.2.47 metabolism the enzyme is involved in the synthesis of the internal alpha-(1->3)-branching of the arabinan domain of arabinogalactan Mycobacterium tuberculosis