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Literature summary extracted from

  • Mitchell, S.; Smith, R.
    A physiological role for flavin-containing monooxygenase (FMO3) in humans (2010), Xenobiotica, 40, 301-305.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.148 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.148 N,N,N-trimethylamine + NADPH + H+ + O2 Homo sapiens
-
 N,N,N-trimethylamine N-oxide + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.148 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.148 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.148 N,N,N-trimethylamine + NADPH + H+ + O2
-
 Homo sapiens N,N,N-trimethylamine N-oxide + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.148 flavin-containing monooxygenase
-
 Homo sapiens
1.14.13.148 FMO3
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.148 FAD
-
 Homo sapiens
1.14.13.148 NADPH required for activity Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.13.148 malfunction FMO3 deficiency results in trimethylaminuria or the fish-like odour syndrome Homo sapiens
1.14.13.148 physiological function isozyme FMO3 regulates the conversion of N,N,N-trimethylamine into its N-oxide and hence controls the release of volatile N,N,N-trimethylamine from the individual Homo sapiens