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Literature summary extracted from

  • Maisetta, G.; Brancatisano, F.; Esin, S.; Campa, M.; Batoni, G.
    Gingipains produced by Porphyromonas gingivalis ATCC49417 degrade human-beta-defensin 3 and affect peptides antibacterial activity in vitro (2011), Peptides, 32, 1073-1077.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.37 leupeptin
-
 Porphyromonas gingivalis
3.4.22.47 cathepsin B inhibitor
-
 Porphyromonas gingivalis

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.37 Porphyromonas gingivalis
-
-
-
3.4.22.47 Porphyromonas gingivalis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.37 human beta-defensin 3 + H2O
-
 Porphyromonas gingivalis ?
-
 ?
3.4.22.47 human beta-defensin 3 + H2O
-
 Porphyromonas gingivalis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.37 gingipain R
-
 Porphyromonas gingivalis
3.4.22.47 gingipain K
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.37 37
-
 assay at Porphyromonas gingivalis
3.4.22.47 37
-
 assay at Porphyromonas gingivalis

General Information

EC Number General Information Comment Organism
3.4.22.37 physiological function results suggest that gingipains may have a role in the resistance of Porphyromonas gingivalis ATCC 49417 to human beta-defensin 3 Porphyromonas gingivalis
3.4.22.47 physiological function results suggest that gingipains may have a role in the resistance of Porphyromonas gingivalis ATCC 49417 to human beta-defensin 3 Porphyromonas gingivalis