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Literature summary extracted from

  • Acosta, D.M.; Soprano, L.L.; Ferrero, M.; Landoni, M.; Esteva, M.I.; Couto, A.S.; Duschak, V.G.
    A striking common O-linked N-acetylglucosaminyl moiety between cruzipain and myosin (2011), Parasite Immunol., 33, 363-370.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.51 lysosome
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 Trypanosoma cruzi 5764
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Organism

EC Number Organism UniProt Comment Textmining
3.4.22.51 Trypanosoma cruzi
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.22.51 glycoprotein single units of O-linked N-acetylglucosamine, usually components of nuclear and cytoplasmatic proteins, are present at the C-terminal domain of cruzipain. They show participation of in the molecular antigenicity of cruzipain. The immune cross-reactivity between cruzipain and myosin, in murine heart tissue, is mainly focused in the C-T domain. The O-GlcNAc moieties constitute a common epitope between cruzipain and either myosin or other cardiac O-GlcNAc-containing proteins Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.51 additional information involvement of O-linked GlcNAc moiety present in the major cysteine protease both in cruzipain recognition and in the cross-reactivity between cruzipain and myosin molecules Trypanosoma cruzi ?
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 ?

General Information

EC Number General Information Comment Organism
3.4.22.51 evolution the O-GlcNAc moieties constitute a common epitope between cruzipain and either myosin or other cardiac O-GlcNAc-containing proteins Trypanosoma cruzi