EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.8 | diallyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | diallyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | diallyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | diallyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | dibutyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | dibutyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | dibutyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | dibutyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | diethyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | diethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | diethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | diethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | dimethyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b]-[1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | dimethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | dimethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica | |
3.4.22.8 | dimethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | - |
Hathewaya histolytica |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.8 | Hathewaya histolytica | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.8 | Nalpha-benzoyl-DL-arginine-4-nitroanilide + H2O | - |
Hathewaya histolytica | Nalpha-benzoyl-DL-arginine + 4-nitroaniline | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.22.8 | 0.032 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | diallyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.036 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | diallyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.07 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | dimethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.08 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | diethyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.09 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | diallyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.14 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | dibutyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.15 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | diallyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.175 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | dibutyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.22 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | diethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.278 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | dimethyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b]-[1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.3 | - |
IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | dibutyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.3 | - |
IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | dimethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.3 | - |
IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | diethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.3 | - |
IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | dibutyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.49 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | diethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate | |
3.4.22.8 | 0.78 | - |
in 100 mM Tris-HCl buffer, pH 7.4, at 37°C | Hathewaya histolytica | dimethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate |