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Literature summary extracted from

  • Kurupati, P.; Turner, C.E.; Tziona, I.; Lawrenson, R.A.; Alam, F.M.; Nohadani, M.; Stamp, G.W.; Zinkernagel, A.S.; Nizet, V.; Edwards, R.J.; Sriskandan, S.
    Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract (2010), Mol. Microbiol., 76, 1387-1397.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.10 160000
-
 gel filtration Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.10 human CXCL-1 + H2O Streptococcus pyogenes the cleavage site is between lysine residues K60 and K61 ?
-
 ?
3.4.22.10 human CXCL-1 + H2O Streptococcus pyogenes H292 the cleavage site is between lysine residues K60 and K61 ?
-
 ?
3.4.22.10 human CXCL-2 + H2O Streptococcus pyogenes the cleavage site is between lysine residues K60 and K61 ?
-
 ?
3.4.22.10 human CXCL-2 + H2O Streptococcus pyogenes H292 the cleavage site is between lysine residues K60 and K61 ?
-
 ?
3.4.22.10 human CXCL-6 + H2O Streptococcus pyogenes
-
 ?
-
 ?
3.4.22.10 human CXCL-6 + H2O Streptococcus pyogenes H292
-
 ?
-
 ?
3.4.22.10 human CXCL-8 + H2O Streptococcus pyogenes
-
 ?
-
 ?
3.4.22.10 human CXCL-8 + H2O Streptococcus pyogenes H292
-
 ?
-
 ?
3.4.22.10 mouse CXCL-1 + H2O Streptococcus pyogenes the cleavage site is between lysine residues K65 and K66 ?
-
 ?
3.4.22.10 mouse CXCL-1 + H2O Streptococcus pyogenes H292 the cleavage site is between lysine residues K65 and K66 ?
-
 ?
3.4.22.10 mouse CXCL-2 + H2O Streptococcus pyogenes the cleavage site is between lysine residues K65 and K66 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.10 Streptococcus pyogenes
-
-
-
3.4.22.10 Streptococcus pyogenes H292
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.10 human CXCL-1 + H2O the cleavage site is between lysine residues K60 and K61 Streptococcus pyogenes ?
-
 ?
3.4.22.10 human CXCL-1 + H2O the cleavage site is between lysine residues K60 and K61 Streptococcus pyogenes H292 ?
-
 ?
3.4.22.10 human CXCL-2 + H2O the cleavage site is between lysine residues K60 and K61 Streptococcus pyogenes ?
-
 ?
3.4.22.10 human CXCL-2 + H2O the cleavage site is between lysine residues K60 and K61 Streptococcus pyogenes H292 ?
-
 ?
3.4.22.10 human CXCL-6 + H2O
-
 Streptococcus pyogenes ?
-
 ?
3.4.22.10 human CXCL-6 + H2O
-
 Streptococcus pyogenes H292 ?
-
 ?
3.4.22.10 human CXCL-8 + H2O
-
 Streptococcus pyogenes ?
-
 ?
3.4.22.10 human CXCL-8 + H2O
-
 Streptococcus pyogenes H292 ?
-
 ?
3.4.22.10 mouse CXCL-1 + H2O the cleavage site is between lysine residues K65 and K66 Streptococcus pyogenes ?
-
 ?
3.4.22.10 mouse CXCL-1 + H2O the cleavage site is between lysine residues K65 and K66 Streptococcus pyogenes H292 ?
-
 ?
3.4.22.10 mouse CXCL-2 + H2O the cleavage site is between lysine residues K65 and K66 Streptococcus pyogenes ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.10 SpcCEP
-
 Streptococcus pyogenes

General Information

EC Number General Information Comment Organism
3.4.22.10 physiological function in infected mice, SpyCEP expression by Streptococcus pyogenes hinders bacterial clearance from muscle, and enhances bacterial spread, associated with cleavage of CXCL1. SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues. SpyCEP enhances Streptococcus pyogenes dissemination to lower respiratory tract from nasopharynx Streptococcus pyogenes