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Literature summary extracted from

  • Dimroth, P.; Hilbi, H.
    Enzymic and genetic basis for bacterial growth on malonate (1997), Mol. Microbiol., 25, 3-10.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.187 gene mdcA, encoded in the malonate decarboxylase operon mdc, genetic organization Klebsiella pneumoniae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.187 60800
-
 x * 60800, isolated acetyl-S-ACP:malonate ACP transferase C-terminal alpha subunit of the malonate decarboxylase complex, SDS-PAGE Klebsiella pneumoniae
2.3.1.187 61200
-
 x * 61200, isolated acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase moiety of the enzyme complex, SDS-PAGE Malonomonas rubra

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.187 malonate + acetyl-[acyl-carrier protein] Klebsiella pneumoniae
-
 acetate + malonyl-[acyl-carrier protein]
-
 ?
2.3.1.187 malonate + acetyl-[acyl-carrier protein] Malonomonas rubra
-
 acetate + malonyl-[acyl-carrier protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.187 Klebsiella pneumoniae
-
 gene mdcA, encoded in the malonate decarboxylase operon mdc
-
2.3.1.187 Malonomonas rubra
-
 gene madA, encoded in the malonate decarboxylase operon mad
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.187 isolated soluble native transferase component of the malonate decarboxylase Malonomonas rubra

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.187 malonate + acetyl-[acyl-carrier protein]
-
 Klebsiella pneumoniae acetate + malonyl-[acyl-carrier protein]
-
 ?
2.3.1.187 malonate + acetyl-[acyl-carrier protein]
-
 Malonomonas rubra acetate + malonyl-[acyl-carrier protein]
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.187 ? x * 60800, isolated acetyl-S-ACP:malonate ACP transferase C-terminal alpha subunit of the malonate decarboxylase complex, SDS-PAGE Klebsiella pneumoniae
2.3.1.187 ? x * 61200, isolated acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase moiety of the enzyme complex, SDS-PAGE Malonomonas rubra

Synonyms

EC Number Synonyms Comment Organism
2.3.1.187 acetyl-S-ACP:malonate ACP transferase
-
 Klebsiella pneumoniae
2.3.1.187 acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase
-
 Malonomonas rubra
2.3.1.187 MadA
-
 Malonomonas rubra
2.3.1.187 MdcA
-
 Klebsiella pneumoniae

General Information

EC Number General Information Comment Organism
2.3.1.187 metabolism to achieve decarboxylation of malonate, the key reaction in the decomposition of this compound, the substrate must be activated by the malonate decarboxylase to a malonyl thio-enzyme ester involving an activation module that comprises the acetylation of a specific thiol group of an acyl carrier protein, ACP, and the transfer of the ACP moiety to malonate, yielding malonyl-S-ACP and acetate. The malonyl-S-ACP is subsequently decarboxylated with regeneration of the acetyl-ACP. Malonate decarboxylation pathway, overview Klebsiella pneumoniae
2.3.1.187 metabolism to achieve decarboxylation of malonate, the key reaction in the decomposition of this compound, the substrate must be activated by the malonate decarboxylase to a malonyl thio-enzyme ester involving an activation module that comprises the acetylation of a specific thiol group of an acyl carrier protein, ACP, and the transfer of the ACP moiety to malonate, yielding malonyl-S-ACP and acetate. The malonyl-S-ACP is subsequently decarboxylated with regeneration of the acetyl-ACP. Malonate decarboxylation pathway, overview Malonomonas rubra
2.3.1.187 additional information the acetyl-S-ACP:malonate ACP transferase is a component of the malonate decarboxylase complex Klebsiella pneumoniae
2.3.1.187 additional information the acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase is a component of the malonate decarboxylase complex Malonomonas rubra